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      Deep learning and radiomics in precision medicine

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          Abstract

          Introduction:

          The radiological reading room is undergoing a paradigm shift to a symbiosis of computer science and radiology using artificial intelligence integrated with machine and deep learning with radiomics to better define tissue characteristics. The goal is to use integrated deep learning and radiomics with radiological parameters to produce a personalized diagnosis for a patient.

          Areas covered:

          This review provides an overview of historical and current deep learning and radiomics methods in the context of precision medicine in radiology. A literature search for ‘Deep Learning’, ‘Radiomics’, ‘Machine learning’, ‘Artificial Intelligence’, ‘Convolutional Neural Network’, ‘Generative Adversarial Network’, ‘Autoencoders’, Deep Belief Networks”, Reinforcement Learning”, and ‘Multiparametric MRI’ was performed in PubMed, ArXiv, Scopus, CVPR, SPIE, IEEE Xplore, and NIPS to identify articles of interest.

          Expert opinion:

          In conclusion, both deep learning and radiomics are two rapidly advancing technologies that will unite in the future to produce a single unified framework for clinical decision support with a potential to completely revolutionize the field of precision medicine.

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          Most cited references99

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          Deep learning.

          Deep learning allows computational models that are composed of multiple processing layers to learn representations of data with multiple levels of abstraction. These methods have dramatically improved the state-of-the-art in speech recognition, visual object recognition, object detection and many other domains such as drug discovery and genomics. Deep learning discovers intricate structure in large data sets by using the backpropagation algorithm to indicate how a machine should change its internal parameters that are used to compute the representation in each layer from the representation in the previous layer. Deep convolutional nets have brought about breakthroughs in processing images, video, speech and audio, whereas recurrent nets have shone light on sequential data such as text and speech.
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            Long Short-Term Memory

            Learning to store information over extended time intervals by recurrent backpropagation takes a very long time, mostly because of insufficient, decaying error backflow. We briefly review Hochreiter's (1991) analysis of this problem, then address it by introducing a novel, efficient, gradient-based method called long short-term memory (LSTM). Truncating the gradient where this does not do harm, LSTM can learn to bridge minimal time lags in excess of 1000 discrete-time steps by enforcing constant error flow through constant error carousels within special units. Multiplicative gate units learn to open and close access to the constant error flow. LSTM is local in space and time; its computational complexity per time step and weight is O(1). Our experiments with artificial data involve local, distributed, real-valued, and noisy pattern representations. In comparisons with real-time recurrent learning, back propagation through time, recurrent cascade correlation, Elman nets, and neural sequence chunking, LSTM leads to many more successful runs, and learns much faster. LSTM also solves complex, artificial long-time-lag tasks that have never been solved by previous recurrent network algorithms.
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              A Mathematical Theory of Communication

              C. Shannon (1948)
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                Author and article information

                Journal
                101686084
                45425
                Expert Rev Precis Med Drug Dev
                Expert Rev Precis Med Drug Dev
                Expert review of precision medicine and drug development
                2380-8993
                1 May 2019
                19 April 2019
                2019
                09 May 2019
                : 4
                : 2
                : 59-72
                Affiliations
                [a ]The Russell H. Morgan Department of Radiology and Radiological Sciences, John Hopkins University, School of Medicine, Baltimore, MD, USA
                [b ]Department of Computer Science, The Johns Hopkins University, Baltimore, MD, USA
                [c ]Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins University School of Medicine, Baltimore, MD, USA
                Author notes
                CONTACT Michael A. Jacobs mikej@ 123456mri.jhu.edu The Russell H. Morgan Department of Radiology and Radiological Science and Oncology, Division of Cancer Imaging, The Johns Hopkins University School of Medicine, Traylor Blg, Rm 309, 712 Rutland Ave, Baltimore, MD 21205, USA

                Author contributions

                VSP and MAJ developed the concept, performed the literature research, and manuscript writing

                Article
                NIHMS1026617
                10.1080/23808993.2019.1585805
                6508888
                31080889
                bf6603c0-a3cb-4648-9738-a1b9dbe7c8b9

                This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License ( http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way.

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                Categories
                Article

                deep learning networks,machine learning,multiparametric radiomics

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