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      The Progress of Glucose Monitoring—A Review of Invasive to Minimally and Non-Invasive Techniques, Devices and Sensors

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          Abstract

          Current glucose monitoring methods for the ever-increasing number of diabetic people around the world are invasive, painful, time-consuming, and a constant burden for the household budget. The non-invasive glucose monitoring technology overcomes these limitations, for which this topic is significantly being researched and represents an exciting and highly sought after market for many companies. This review aims to offer an up-to-date report on the leading technologies for non-invasive (NI) and minimally-invasive (MI) glucose monitoring sensors, devices currently available in the market, regulatory framework for accuracy assessment, new approaches currently under study by representative groups and developers, and algorithm types for signal enhancement and value prediction. The review also discusses the future trend of glucose detection by analyzing the usage of the different bands in the electromagnetic spectrum. The review concludes that the adoption and use of new technologies for glucose detection is unavoidable and closer to become a reality.

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          Most cited references182

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          Electrode systems for continuous monitoring in cardiovascular surgery.

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            Nanomaterials enhanced surface plasmon resonance for biological and chemical sensing applications.

            The main challenge for all electrical, mechanical and optical sensors is to detect low molecular weight (less than 400 Da) chemical and biological analytes under extremely dilute conditions. Surface plasmon resonance sensors are the most commonly used optical sensors due to their unique ability for real-time monitoring the molecular binding events. However, their sensitivities are insufficient to detect trace amounts of small molecular weight molecules such as cancer biomarkers, hormones, antibiotics, insecticides, and explosive materials which are respectively important for early-stage disease diagnosis, food quality control, environmental monitoring, and homeland security protection. With the rapid development of nanotechnology in the past few years, nanomaterials-enhanced surface plasmon resonance sensors have been developed and used as effective tools to sense hard-to-detect molecules within the concentration range between pmol and amol. In this review article, we reviewed and discussed the latest trend and challenges in engineering and applications of nanomaterials-enhanced surface plasmon resonance sensors (e.g., metallic nanoparticles, magnetic nanoparticles, carbon-based nanomaterials, latex nanoparticles and liposome nanoparticles) for detecting "hard-to-identify" biological and chemical analytes. Such information will be viable in terms of providing a useful platform for designing future ultrasensitive plasmonic nanosensors.
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              Optical coherence tomography - principles and applications

                Author and article information

                Journal
                Sensors (Basel)
                Sensors (Basel)
                sensors
                Sensors (Basel, Switzerland)
                MDPI
                1424-8220
                15 February 2019
                February 2019
                : 19
                : 4
                : 800
                Affiliations
                School of Information Technology and Electrical Engineering, The University of Queensland, St Lucia, Brisbane 4072, Australia; a.mobashsher@ 123456uq.edu.au (A.T.M.); a.abbosh@ 123456uq.edu.au (A.A.)
                Author notes
                [* ]Correspondence: w.villena@ 123456uq.edu.au ; Tel.: +61-07-3365-8354
                Author information
                https://orcid.org/0000-0002-7299-6885
                https://orcid.org/0000-0002-6351-8136
                Article
                sensors-19-00800
                10.3390/s19040800
                6412701
                30781431
                bf673590-7d42-433e-b91b-a1349ee414bf
                © 2019 by the authors.

                Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license ( http://creativecommons.org/licenses/by/4.0/).

                History
                : 31 October 2018
                : 22 January 2019
                Categories
                Review

                Biomedical engineering
                glucose,non-invasive,minimally-invasive,spectroscopy,continuous monitoring,mard,fda,iso 15197,plasmon resonance,fluorescence,ultrasound,metabolic heat conformation

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