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The effects of supplementary taurine on the essential element status and antioxidant indices in the kidney of aluminum-exposed rats

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      Abstract

      Abstract: Objective: Our experiment was undertaken to explore the positive effects of taurine (Tau) on the redox system and essential elements in the kidney of aluminum (Al)-exposed rats. Material and methods: The whole experiment included two periods, exposure period and detoxification period, of 4 weeks each (as verified by our previous studies). 42 male Wistar rats were randomly divided into 6 groups: control group (1.0 mL/kg/day, saline, 8 weeks), Al exposure group (281.40 mg/kg/day AlCl 3 ·6H 2 O for 4 weeks during the exposure period and 1.0 mL/kg/day, saline for 4 weeks during the detoxification period), low-, medium-, and high-dose Tau groups (281.40 mg/kg/day AlCl 3 ·6H 2 O for 4 weeks during the exposure period and 200 mg/kg/day, 400 mg/kg/day, 800 mg/kg/day Tau, respectively, for 4 weeks during the detoxification period), and Tau prevention group (281.40 mg/kg/day AlCl 3 ·6H 2 O with 400 mg/kg/day Tau 4 hours after Al administration for 4 weeks during the exposure period and 400 mg/kg Tau for 4 weeks during the detoxification period). Both Al and Tau were dissolved in saline. The markers of oxidative stress, activities of antioxidant enzymes, and essential elements in the kidney were determined. Results: Al exposure caused a significant reduction in the activities of antioxidant enzymes and an elevation of malondialdehyde (MDA) in the kidney (p < 0.05). In addition, Al intake resulted in significant (p < 0.05) deficits of the essential elements copper (Cu), magnesium (Mg), and iron (Fe). However, Tau supplementation showed an improvement of the activities of antioxidant enzymes and of the levels of essential elements, evidenced by increases in glutathione peroxidase (GSH-Px), superoxide dismutase (SOD), levels of Cu, Mg, and Fe as well as by a decrease in MDA (p < 0.05). Conclusions: Tau may be a promising intervention for Al-induced nephrotoxicity through ameliorating the impairment of oxidative stress and modulating the levels of essential elements.


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      Most cited references 6

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      Physiological actions of taurine

       R. Huxtable (1992)
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        Copper and carcinogenesis.

        Metal ions play an important role in biological systems, and without their catalytic presence in trace or ultratrace amounts many essential co-factors for many biochemical reactions would not take place. However, they become toxic to cells when their concentrations surpass certain optimal (natural) levels. Copper is an essential metal. Catalytic copper, because of its mobilization and redox activity, is believed to play a central role in the formation of reactive oxygen species (ROS), such as O2-* and *OH radicals, that bind very fast to DNA, and produce damage by breaking the DNA strands or modifying the bases and/or deoxyribose leading to carcinogenesis. The chemistry and biochemistry of copper is briefly accounted together with its involvement in cancer and other diseases.
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          Serum ceruloplasmin and copper levels in patients with primary brain tumors.

          Serum copper and ceruloplasmin levels are known to increase in several malignancies such as osteosarcomas, some gastrointestinal tumors, and lung cancer. In this study serum copper and ceruloplasmin levels in 40 patients with primary brain tumors were studied. Both parameters were increased in sera of patients with tumors in comparison with healthy subjects or patients with non-tumorous neurological diseases. It is concluded that copper and ceruloplasmin represent a good complement to some other nonspecific parameters in evaluating the activity of malignancy and the therapeutic results.
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            Author and article information

            Journal
            Trace Elements and Electrolytes
            TE
            Dustri-Verlgag Dr. Karl Feistle
            0946-2104
            2017
            April 01 2017
            : 34
            : 04
            : 62-67
            10.5414/TEX01455
            © 2017

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