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      Vascular Resistance and Reactivity in Hypertensive Rats

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          Abstract

          Vascular resistance of the perfused whole body and isolated hindquarters was increased using preparations from renal, deoxycorticosterone/NaCl and genetic hypertensive rats. An increased reactivity to injected noradrenaline was observed in isolated perfused hindquarters from all three types of hypertensive rats. In depolarized mesenteric artery preparations, the calcium dose-response curves in preparations from normotensive and hypertensive rats were similar. The results point to structural changes of the blood vessels and a cellular hyperreactivity involving the process of excitation-contraction-coupling.

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          Author and article information

          Journal
          JVR
          J Vasc Res
          10.1159/issn.1018-1172
          Journal of Vascular Research
          S. Karger AG
          1018-1172
          1423-0135
          1974
          1974
          18 September 2008
          : 11
          : 3
          : 145-158
          Affiliations
          Department of Experimental Medicine, F. Hoffmann-La Roche & Co. Ltd., Basel
          Article
          158008 Blood Vessels 1974;11:145–158
          10.1159/000158008
          © 1974 S. Karger AG, Basel

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          Page count
          Pages: 14
          Categories
          Research Paper

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