7
views
0
recommends
+1 Recommend
0 collections
    0
    shares
      • Record: found
      • Abstract: found
      • Article: not found

      Prefrontal cortical BDNF: A regulatory key in cocaine- and food-reinforced behaviors

      Read this article at

      ScienceOpenPublisherPMC
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          Brain-derived neurotrophic factor (BDNF) affects synaptic plasticity and neural structure and plays key roles in learning and memory processes. Recent evidence also points to important, yet complex, roles for BDNF in rodent models of cocaine abuse and addiction. Here we examine the role of prefrontal cortical (PFC) BDNF in reward-related decision making and behavioral sensitivity to, and responding for, cocaine. We focus on BDNF within the medial and orbital PFC, its regulation by cocaine during early postnatal development and in adulthood, and how BDNF in turn influences responding for drug reinforcement, including in reinstatement models. When relevant, we draw comparisons and contrasts with experiments using natural (food) reinforcers. We also summarize findings supporting, or refuting, the possibility that BDNF in the medial and orbital PFC regulate the development and maintenance of stimulus-response habits. Further investigation could assist in the development of novel treatment approaches for cocaine use disorders.

          Related collections

          Author and article information

          Journal
          9500169
          20475
          Neurobiol Dis
          Neurobiol. Dis.
          Neurobiology of disease
          0969-9961
          1095-953X
          29 April 2016
          26 February 2016
          July 2016
          01 July 2017
          : 91
          : 326-335
          Affiliations
          [1 ]Graduate Program in Neuroscience, Yerkes National Primate Research Center, Emory University, Atlanta, GA
          [2 ]Department of Psychiatry, Yale University School of Medicine, Interdepartmental Neuroscience Program, Department of Psychology, Yale University, New Haven, CT
          [3 ]Departments of Pediatrics and Psychiatry and Behavioral Sciences, Emory University School of Medicine, Graduate Program in Neuroscience, Yerkes National Primate Research Center, Emory University, Atlanta, GA
          Author notes
          Contact: Shannon L. Gourley, PhD, Yerkes National Primate Research Center, 954 Gatewood Dr. NE, Atlanta GA 30329, 404-727-2482, shannon.l.gourley@ 123456emory.edu
          Article
          PMC4913044 PMC4913044 4913044 nihpa781449
          10.1016/j.nbd.2016.02.021
          4913044
          26923993
          Categories
          Article

          Comments

          Comment on this article