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      Controlled Release of Plectasin NZ2114 from a Hybrid Silicone-Hydrogel Material for Inhibition of Staphylococcus aureus Biofilm

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          ABSTRACT

          Staphylococcus aureus is a major human pathogen in catheter-related infections. Modifying catheter material with interpenetrating polymer networks is a novel material technology that allows for impregnation with drugs and subsequent controlled release. Here, we evaluated the potential for combining this system with plectasin derivate NZ2114 in an attempt to design an S. aureus biofilm-resistant catheter. The material demonstrated promising antibiofilm properties, including properties against methicillin-resistant S. aureus, thus suggesting a novel application of this antimicrobial peptide.

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          Author and article information

          Journal
          Antimicrob Agents Chemother
          Antimicrob. Agents Chemother
          aac
          aac
          AAC
          Antimicrobial Agents and Chemotherapy
          American Society for Microbiology (1752 N St., N.W., Washington, DC )
          0066-4804
          1098-6596
          15 May 2017
          27 June 2017
          July 2017
          : 61
          : 7
          : e00604-17
          Affiliations
          [a ]Research Unit of Clinical Microbiology, University of Southern Denmark and Odense University Hospital, Odense, Denmark
          [b ]Biomodics ApS, Taastrup, Denmark
          [c ]Novozymes A/S, Animal Health & Nutrition, Bagsværd, Denmark
          Author notes
          Address correspondence to Thomas Emil Andersen, thandersen@ 123456health.sdu.dk .

          Citation Klein K, Grønnemose RB, Alm M, Brinch KS, Kolmos HJ, Andersen TE. 2017. Controlled release of plectasin NZ2114 from a hybrid silicone-hydrogel material for inhibition of Staphylococcus aureus biofilm. Antimicrob Agents Chemother 61:e00604-17. https://doi.org/10.1128/AAC.00604-17.

          Article
          PMC5487675 PMC5487675 5487675 00604-17
          10.1128/AAC.00604-17
          5487675
          28507110
          bfc13af0-5257-4607-bcc5-7c7f99780782
          Copyright © 2017 American Society for Microbiology.

          All Rights Reserved.

          History
          : 29 March 2017
          : 18 April 2017
          Page count
          Figures: 4, Tables: 3, Equations: 0, References: 15, Pages: 6, Words: 2961
          Funding
          Funded by: Innovation Fund Denmark
          Award ID: 52-2014-1
          Award Recipient : Thomas Emil Andersen
          Funded by: Innovation Fund Denmark
          Award ID: 41-2010-3
          Award Recipient : Hans Jørn Kolmos
          Categories
          Experimental Therapeutics
          Custom metadata
          July 2017

          Staphylococcus aureus ,antimicrobial peptides,plectasin,biofilm formation,catheter infections,biofilms,catheter,hydrogel

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