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      18F-FDG PET-CT for Evaluation of Cardiac Angiosarcoma: A Case Report and Review of Literature Translated title: Kardiyak Anjiosarkomun İncelenmesi için 18F-FDG PET-BT: Bir Olgu Sunumu ve Literatür Derlemesi

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          Abstract

          Cardiac angiosarcomas are rare neoplasms. We here present the case of a 24 year old male with a cardiac mass which was characterised as malignant on 18F-Fluorodeoxyglucose (18F-FDG) positron emission tomography-computed tomography (PET-CT). In addition 18F-FDG PET-CT also demonstrated pericardial infiltration and bone metastases. The tumor was confirmed to be angiosarcoma on biopsy and palliative chemotherapy was started. Here we have highlighted the potential role of 18F-FDG PET-CT in patients with cardiac angiosarcoma and presented a brief review.

          Translated abstract

          Kardiyak anjiyosarkomlar nadir neoplazilerdir. Bu makalede 18F-Florodeoksiglukoz (18F-FDG) pozitron emisyon tomografi-bilgisayarlı tomografi (PET-BT) ile malin olduğu saptanan kardiyak kitlesi olan 24 yaşında bir olguyu sunduk. 18F-FDG PET-BT aynı zamanda perikardiyal infiltrasyon ve kemik metastazını da gösterdi. Tümör, biyopsi sonucunda anjiyosarkom olarak doğrulandı ve palyatif kemoterapiye başlandı. Bu makalede kardiyak anjiyosarkomlu hastalarda 18F-FDG PET-BT’nin potansiyel rolünü vurguladık ve kısa bir derleme sunduk.

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          Most cited references 23

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          Cardiac angiosarcoma: two cases and a review of the literature.

           J Butany,  Weiping Yu (2000)
          Primary cardiac tumours are rare, and primary malignant cardiac tumours even rarer. Of these, cardiac angiosarcomas are uncommon and, until recently, almost invariably diagnosed at the time of autopsy, primarily because the symptoms are initially nonspecific and do not become manifest until the tumour is advanced. Two patients, who presented in quite different manners and were diagnosed at autopsy and at open surgical biopsy, are presented. The literature on cardiac angiosarcomas is reviewed critically, with emphasis on presentation and morphology. This review of the literature shows that, with increasing availability of newer diagnostic tools, especially noninvasive ones, diagnosis of this rare lesion can be made at an early stage and confirmed at cardiac biopsy or cardiac surgery. Unfortunately, so far, the results remain virtually uniformly poor, though occasionally survival at up to 53 months has been reported.
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            Successful treatment of primary cardiac angiosarcoma with docetaxel and radiotherapy.

            A 49-year-old man was admitted for primary cardiac angiosarcoma with a cardiac tamponade. Transthoracic echocardiography and contrast-enhanced computed tomography scan demonstrated a large mass in the right atrium and thickening of the right ventricular wall. 18F-labeled deoxyglucose (FDG) positron emission tomography (PET) scan showed increased FDG uptake in the mediastinum and over the heart. The patient responded to combination therapy with docetaxel and radiotherapy and tolerated the treatment well, except for radiation esophagitis, which required a soft diet and resolved 1 month after treatment. This combination therapy resulted in a minimal response with slight regression in the tumor size, but FDG-PET initially showed an increase in FDG uptake by the tumor that was no longer seen after combination therapy. There is no evidence of progression or metastasis even at 12 months after diagnosis.
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              Successful surgical excision of primary right atrial angiosarcoma

              Primary cardiac angiosarcoma is a rare and aggressive tumor with a high incidence of metastatic spread (up to 89%) at the time of diagnosis, which restricts the indication for surgical resection to a small number of patients. We report the case of a 50-year old Caucasian woman with non-metastatic primary right atrial angiosarcoma, who underwent successful surgical excision of the tumor (with curative intent) and reconstruction of the right atrium with a porcine pericardial patch. However, after a symptom-free survival of five months the patient presented with bone and liver metastases without evidence of local tumor recurrence.
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                Author and article information

                Journal
                Mol Imaging Radionucl Ther
                Mol Imaging Radionucl Ther
                MIRT
                Molecular Imaging and Radionuclide Therapy
                Galenos Publishing
                2146-1414
                2147-1959
                February 2015
                15 February 2015
                : 24
                : 1
                : 32-36
                Affiliations
                [1 ] All India Institute of Medical Sciences, Department of Nuclear Medicine, New Delhi, India
                [2 ] All India Institute of Medical Sciences, Department of Radiodiagnosis, New Delhi, India
                Author notes
                * Address for Correspondence: All India Institute of Medical Sciences, Department of Nuclear Medicine, New Delhi, India Phone: 91-11-28-6594472 E-mail: rkphulia@ 123456hotmail.com
                Article
                1380
                10.4274/mirt.02486
                4372771
                25800597
                © Molecular Imaging and Radionuclide Therapy, Published by Galenos Publishing.

                This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

                Categories
                Case Report

                hemangiosarcoma, heart, pet scan, 18f-fdg, bone, metastasis

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