18F-FDG PET-CT for Evaluation of Cardiac Angiosarcoma: A Case Report and Review of Literature

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Abstract

Cardiac angiosarcomas are rare neoplasms. We here present the case of a 24 year old male with a cardiac mass which was characterised as malignant on 18F-Fluorodeoxyglucose (18F-FDG) positron emission tomography-computed tomography (PET-CT). In addition 18F-FDG PET-CT also demonstrated pericardial infiltration and bone metastases. The tumor was confirmed to be angiosarcoma on biopsy and palliative chemotherapy was started. Here we have highlighted the potential role of 18F-FDG PET-CT in patients with cardiac angiosarcoma and presented a brief review.

Translated abstract

Kardiyak anjiyosarkomlar nadir neoplazilerdir. Bu makalede 18F-Florodeoksiglukoz (18F-FDG) pozitron emisyon tomografi-bilgisayarlı tomografi (PET-BT) ile malin olduğu saptanan kardiyak kitlesi olan 24 yaşında bir olguyu sunduk. 18F-FDG PET-BT aynı zamanda perikardiyal infiltrasyon ve kemik metastazını da gösterdi. Tümör, biyopsi sonucunda anjiyosarkom olarak doğrulandı ve palyatif kemoterapiye başlandı. Bu makalede kardiyak anjiyosarkomlu hastalarda 18F-FDG PET-BT’nin potansiyel rolünü vurguladık ve kısa bir derleme sunduk.

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Cardiac angiosarcoma: two cases and a review of the literature.

J Butany, Weiping Yu (2000)

Primary cardiac tumours are rare, and primary malignant cardiac tumours even rarer. Of these, cardiac angiosarcomas are uncommon and, until recently, almost invariably diagnosed at the time of autopsy, primarily because the symptoms are initially nonspecific and do not become manifest until the tumour is advanced. Two patients, who presented in quite different manners and were diagnosed at autopsy and at open surgical biopsy, are presented. The literature on cardiac angiosarcomas is reviewed critically, with emphasis on presentation and morphology. This review of the literature shows that, with increasing availability of newer diagnostic tools, especially noninvasive ones, diagnosis of this rare lesion can be made at an early stage and confirmed at cardiac biopsy or cardiac surgery. Unfortunately, so far, the results remain virtually uniformly poor, though occasionally survival at up to 53 months has been reported.

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Primary cardiac angiosarcoma: a clinicopathologic study of six cases.

Marie Herrmann, Robert A. Shankerman, William Edwards … (1992)

Autopsy or surgical specimens from six patients with primary cardiac angiosarcoma seen at the Mayo Clinic (all in men) between 1939 and 1988 were studied (patients' ages, 31 to 80 years; mean 50 years). The symptoms were nonspecific and included dyspnea and thoracoabdominal pain in six; anorexia in five; fatigue, hemoptysis, or orthopnea in four; nausea and vomiting, fever, or weight loss in three; and night sweats in two. Cardiomegaly was present in five, and a pericardial effusion or density, a mass adjacent to the heart, or nonspecific ST-T wave changes were present in three. All six neoplasms arose from the right atrium and exhibited epicardial or endocardial extension; three produced obstructive intracavitary right atrial masses. Pulmonary metastatic lesions were noted in five patients. The cardiac neoplasm was diagnosed by computed tomography or magnetic resonance imaging in the three most recent patients, and surgical resection was performed in two of them. Mean survival was 6 months after presentation. Causes of death were pulmonary hemorrhage in three, thoracic metastasis in two, and hemopericardium in one. The diagnosis of primary cardiac angiosarcoma was established at operation in two patients and at autopsy in four. Despite diagnosis by noninvasive imaging procedures and aggressive early surgical intervention, survival was less than 6 months. Thus optimal therapy is unclear.

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Successful surgical excision of primary right atrial angiosarcoma

Wobbe Bouma, Chris Lexis, Tineke Willems … (2011)

Primary cardiac angiosarcoma is a rare and aggressive tumor with a high incidence of metastatic spread (up to 89%) at the time of diagnosis, which restricts the indication for surgical resection to a small number of patients. We report the case of a 50-year old Caucasian woman with non-metastatic primary right atrial angiosarcoma, who underwent successful surgical excision of the tumor (with curative intent) and reconstruction of the right atrium with a porcine pericardial patch. However, after a symptom-free survival of five months the patient presented with bone and liver metastases without evidence of local tumor recurrence.

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Author and article information

Journal

Journal ID (nlm-ta): Mol Imaging Radionucl Ther

Journal ID (iso-abbrev): Mol Imaging Radionucl Ther

Journal ID (publisher-id): MIRT

Title: Molecular Imaging and Radionuclide Therapy

Publisher: Galenos Publishing

ISSN (Print): 2146-1414

ISSN (Electronic): 2147-1959

Publication date (Print): February 2015

Publication date (Electronic): 15 February 2015

Volume: 24

Issue: 1

Pages: 32-36

Affiliations

[1 ] All India Institute of Medical Sciences, Department of Nuclear Medicine, New Delhi, India

[2 ] All India Institute of Medical Sciences, Department of Radiodiagnosis, New Delhi, India

Author notes

* Address for Correspondence: All India Institute of Medical Sciences, Department of Nuclear Medicine, New Delhi, India Phone: 91-11-28-6594472 E-mail: rkphulia@ 123456hotmail.com

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Publisher ID: 1380

DOI: 10.4274/mirt.02486

PMC ID: 4372771

PubMed ID: 25800597

SO-VID: bfe3241d-f88f-4715-916a-30d2a90a5028

License:

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

18F-FDG PET-CT for Evaluation of Cardiac Angiosarcoma: A Case Report and Review of Literature Translated title: Kardiyak Anjiosarkomun İncelenmesi için 18F-FDG PET-BT: Bir Olgu Sunumu ve Literatür Derlemesi

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NeuroImaging Methods

Most cited references 22

Cardiac angiosarcoma: two cases and a review of the literature.

Primary cardiac angiosarcoma: a clinicopathologic study of six cases.

Successful surgical excision of primary right atrial angiosarcoma

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