Fibrin-based Bioinks: New Tricks from an Old Dog

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Abstract

For the past 10 years, the main efforts of most bioprinting research teams have focused on creating new bioink formulations, rather than inventing new printing set-up concepts. New tissue-specific bioinks with good printability, shape fidelity, and biocompatibility are based on “old” (well-known) biomaterials, particularly fibrin. While the interest in fibrin-based bioinks is constantly growing, it is essential to provide a framework of material’s properties and trends. This review aims to describe the fibrin properties and application in three-dimensional bioprinting and provide a view on further development of fibrin-based bioinks.

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Platelet-rich fibrin (PRF): a second-generation platelet concentrate. Part I: technological concepts and evolution.

David Dohan, Joseph Choukroun, Antoine Diss … (2006)

Platelet-rich fibrin (PRF) belongs to a new generation of platelet concentrates geared to simplified preparation without biochemical blood handling. In this initial article, we describe the conceptual and technical evolution from fibrin glues to platelet concentrates. This retrospective analysis is necessary for the understanding of fibrin technologies and the evaluation of the biochemical properties of 3 generations of surgical additives, respectively fibrin adhesives, concentrated platelet-rich plasma (cPRP) and PRF. Indeed, the 3-dimensional fibrin architecture is deeply dependent on artificial clinical polymerization processes, such as massive bovine thrombin addition. Currently, the slow polymerization during PRF preparation seems to generate a fibrin network very similar to the natural one. Such a network leads to a more efficient cell migration and proliferation and thus cicatrization.

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Platelet-rich fibrin (PRF): a second-generation platelet concentrate. Part III: leucocyte activation: a new feature for platelet concentrates?

David Dohan, Joseph Choukroun, Antoine Diss … (2006)

Platelet-rich fibrin (PRF) belongs to a new generation of platelet concentrates, with simplified processing and without biochemical blood handling. In this third article, we investigate the immune features of this biomaterial. During PRF processing, leucocytes could also secrete cytokines in reaction to the hemostatic and inflammatory phenomena artificially induced in the centrifuged tube. We therefore undertook to quantify 5 significant cell mediators within platelet poor plasma supernatant and PRF clot exudate serum: 3 proinflammatory cytokines (IL-1beta, IL-6, and TNF-alpha), an antiinflammatory cytokine (IL-4), and a key growth promoter of angiogenesis (VEGF). Our data are correlated with that obtained in plasma (nonactivated blood) and in sera (activated blood). These initial analyses revealed that PRF could be an immune regulation node with inflammation retrocontrol abilities. This concept could explain the reduction of postoperative infections when PRF is used as surgical additive.

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A comprehensive review on droplet-based bioprinting: Past, present and future.

Hemanth Gudapati, Madhuri Dey, Ibrahim Tarik Ozbolat (2016)

Droplet-based bioprinting (DBB) offers greater advantages due to its simplicity and agility with precise control on deposition of biologics including cells, growth factors, genes, drugs and biomaterials, and has been a prominent technology in the bioprinting community. Due to its immense versatility, DBB technology has been adopted by various application areas, including but not limited to, tissue engineering and regenerative medicine, transplantation and clinics, pharmaceutics and high-throughput screening, and cancer research. Despite the great benefits, the technology currently faces several challenges such as a narrow range of available bioink materials, bioprinting-induced cell damage at substantial levels, limited mechanical and structural integrity of bioprinted constructs, and restrictions on the size of constructs due to lack of vascularization and porosity. This paper presents a first-time review of DBB and comprehensively covers the existing DBB modalities including inkjet, electrohydrodynamic, acoustic, and micro-valve bioprinting. The recent notable studies are highlighted, the relevant bioink biomaterials and bioprinters are expounded, the application areas are presented, and the future prospects are provided to the reader.

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Author and article information

Journal

Journal ID (nlm-ta): Int J Bioprint

Journal ID (iso-abbrev): Int J Bioprint

Journal ID (publisher-id): Whioce Publishing Pte. Ltd.

Title: International Journal of Bioprinting

Publisher: Whioce Publishing Pte. Ltd.

ISSN (Print): 2424-7723

ISSN (Electronic): 2424-8002

Publication date Collection: 2020

Publication date (Electronic): 29 April 2020

Volume: 6

Issue: 3

Electronic Location Identifier: 269

Affiliations

[1 ]Department of Advanced Biomaterials, Institute for Regenerative Medicine, Sechenov First Moscow State Medical University, Moscow, Russia

[2 ]Department of Chemistry, Lomonosov Moscow State University, Moscow, Russia

[3 ]Department of Molecular and Cell Pathophysiology, FSBSI Institute of General Pathology and Pathophysiology, Moscow, Russia

[4 ]Department of Embryology, Lomonosov Moscow State University, Faculty of Biology, Moscow, Russia

[5 ]Department of Traumatology, Orthopedics and Disaster Surgery, Sechenov First Moscow State Medical University, Moscow, Russia

[6 ]Department of Urology, Sechenov First Moscow State Medical University, Moscow, Russia

[7 ]Department of Polymers and Composites, NN Semenov Institute of Chemical Physics, Moscow, Russia

[8 ]Department of Regenerative Medicine, Cell Science Research Centre, Royan Institute for Stem Cell Biology and Technology, ACECR, Tehran, Iran

[9 ]Institute of Photon Technologies, Federal Research Center Crystallography and Photonics RAS, Moscow, Russia

Author notes

[* ] Corresponding Author: Anastasia Shpichka, Department of Advanced Biomaterials, Institute for Regenerative Medicine, Sechenov First Moscow State Medical University, Moscow, Russia; ana-shpichka@ 123456yandex.ru

Article

Publisher ID: IJB-6-3-269

DOI: 10.18063/ijb.v6i3.269

PMC ID: 7557349

SO-VID: bff036dd-4444-4159-a6fc-cee28269bb7c

License:

This is an open-access article distributed under the terms of the Attribution-NonCommercial 4.0 International 4.0 (CC BY-NC 4.0), which permits all non-commercial use, distribution, and reproduction in any medium provided the original work is properly cited.

Fibrin-based Bioinks: New Tricks from an Old Dog

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Most cited references 100

Platelet-rich fibrin (PRF): a second-generation platelet concentrate. Part I: technological concepts and evolution.

Platelet-rich fibrin (PRF): a second-generation platelet concentrate. Part III: leucocyte activation: a new feature for platelet concentrates?

A comprehensive review on droplet-based bioprinting: Past, present and future.

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