+1 Recommend
0 collections
      • Record: found
      • Abstract: found
      • Article: not found

      Effect of interferon-lambda on replication of hepatitis B virus in human hepatoma cells.

      Virus Research
      Antigens, Viral, biosynthesis, Cell Line, Tumor, Cytokines, pharmacology, Gene Expression, Genome, Viral, drug effects, Hepatitis B virus, genetics, immunology, physiology, Humans, Interleukins, Receptors, Interferon, Recombinant Proteins, Transcription, Genetic, Virus Replication

      Read this article at

          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.


          The antiviral activity of interferon-lambda (IFN-lambda) against several viruses has been reported, but it has not been investigated whether human IFN-lambda can affect replication of the hepatitis B virus (HBV) in human hepatocyte-derived cells. We found that replication of HBV in a human hepatoma cell line was reduced by approximately 30% following treatment with a high concentration of IFN-lambda. Furthermore, we showed that replication of HBV in another human hepatoma cell line was not suppressed by IFN-lambda. However, these cell lines showed a similar level of transcription for the heterodimeric IFN-lambda receptor and the IFN-lambda-induced antiviral proteins. Our results suggest that the antiviral activity of IFN-lambda against HBV may be limited in human cells.

          Related collections

          Author and article information


          Comment on this article