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      Effect of interferon-lambda on replication of hepatitis B virus in human hepatoma cells.

      Virus Research
      Antigens, Viral, biosynthesis, Cell Line, Tumor, Cytokines, pharmacology, Gene Expression, Genome, Viral, drug effects, Hepatitis B virus, genetics, immunology, physiology, Humans, Interleukins, Receptors, Interferon, Recombinant Proteins, Transcription, Genetic, Virus Replication

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          Abstract

          The antiviral activity of interferon-lambda (IFN-lambda) against several viruses has been reported, but it has not been investigated whether human IFN-lambda can affect replication of the hepatitis B virus (HBV) in human hepatocyte-derived cells. We found that replication of HBV in a human hepatoma cell line was reduced by approximately 30% following treatment with a high concentration of IFN-lambda. Furthermore, we showed that replication of HBV in another human hepatoma cell line was not suppressed by IFN-lambda. However, these cell lines showed a similar level of transcription for the heterodimeric IFN-lambda receptor and the IFN-lambda-induced antiviral proteins. Our results suggest that the antiviral activity of IFN-lambda against HBV may be limited in human cells.

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