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      Ultrasound and Intra-clot Microbubbles Enhanced Catheter-Directed Thrombolysis in Vitro and in Vivo.

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          Abstract

          Insufficient penetration of microbubbles (MBs) into the vessel-obstructing thrombi significantly reduces the effectiveness of ultrasound thrombolysis (UT). The widely performed catheter-directed therapy (CDT) makes it possible to increase the local concentration of MBs in the clot. In an occluded vessel with a bypass, treatment of fresh human whole blood clots with CDT-based UT (intra-clot injection of MBs and urokinase, with ultrasound exposure) resulted in a significantly higher percentage of weight loss (35.32 ± 15.42%), compared with CDT alone (19.64 ± 4.71%), non-CDT-based UT (systemic administration of urokinase and MBs, with ultrasound exposure, 8.79 ± 3.02%) and systemic thrombolysis (7.90 ± 2.14). Ultrasound and intra-clot MB enhancement of CDT was further confirmed by a rabbit IVC thrombolysis study, where CDT-based UT resulted in significantly more effective thrombolysis compared with CDT alone. In summary, combining CDT with intra-clot MB-induced acoustic cavitation can improve thrombolysis.

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          Author and article information

          Journal
          Ultrasound Med Biol
          Ultrasound in medicine & biology
          Elsevier BV
          1879-291X
          0301-5629
          May 04 2017
          Affiliations
          [1 ] Department of Ultrasound, Xinqiao Hospital, Third Military Medical University, Chongqing, China.
          [2 ] Department of Ultrasound, Xinqiao Hospital, Third Military Medical University, Chongqing, China. Electronic address: liuzhengs@hotmail.com.
          [3 ] Internal Medicine Cardiology, University of Nebraska Medical Center, Omaha, Nebraska, USA.
          Article
          S0301-5629(17)30139-4
          10.1016/j.ultrasmedbio.2017.03.017
          28479088
          bfffcdeb-f23a-460d-998e-ed5b523b0d29
          History

          Catheter-directed technique,Microbubbles,Thrombolysis,Ultrasound

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