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      Acute administration of ucf-101 ameliorates the locomotor impairments induced by a traumatic spinal cord injury.

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          Abstract

          Secondary death of neural cells plays a key role in the physiopathology and the functional consequences of traumatic spinal cord injury (SCI). Pharmacological manipulation of cell death pathways leading to the preservation of neural cells is acknowledged as a main therapeutic goal in SCI. In the present work, we hypothesize that administration of the neuroprotective cell-permeable compound ucf-101 will reduce neural cell death during the secondary damage of SCI, increasing tissue preservation and reducing the functional deficits. To test this hypothesis, we treated mice with ucf-101 during the first week after a moderate contusive SCI. Our results reveal that ucf-101 administration protects neural cells from the deleterious secondary mechanisms triggered by the trauma, reducing the extension of tissue damage and improving motor function recovery. Our studies also suggest that the effects of ucf-101 may be mediated through the inhibition of HtrA2/OMI and the concomitant increase of inhibitor of apoptosis protein XIAP, as well as the induction of ERK1/2 activation and/or expression. In vitro assays confirm the effects of ucf-101 on both pathways as well as on the reduction of caspase cascade activation and apoptotic cell death in a neuroblastoma cell line. These results suggest that ucf-101 can be a promising therapeutic tool for SCI that deserves more detailed analyses.

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          Author and article information

          Journal
          Neuroscience
          Neuroscience
          Elsevier BV
          1873-7544
          0306-4522
          Aug 06 2015
          : 300
          Affiliations
          [1 ] Molecular Neuroprotection Group, Experimental Neurology Unit, Hospital Nacional de Parapléjicos (SESCAM), Finca La Peraleda s/n, 45071 Toledo, Spain. Electronic address: dreigada@sescam.jccm.es.
          [2 ] Molecular Neuroprotection Group, Experimental Neurology Unit, Hospital Nacional de Parapléjicos (SESCAM), Finca La Peraleda s/n, 45071 Toledo, Spain.
          [3 ] Molecular Neuroprotection Group, Experimental Neurology Unit, Hospital Nacional de Parapléjicos (SESCAM), Finca La Peraleda s/n, 45071 Toledo, Spain. Electronic address: rodrigom@sescam.jccm.es.
          Article
          S0306-4522(15)00478-9
          10.1016/j.neuroscience.2015.05.036
          26004679
          c00645f7-1045-4e73-a98f-bf9a03522adb
          History

          XIAP,HtrA2/OMI,apoptosis,neuroprotection,pERK1/2,spinal cord
          XIAP, HtrA2/OMI, apoptosis, neuroprotection, pERK1/2, spinal cord

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