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      Infralimbic prefrontal cortex interacts with nucleus accumbens shell to unmask expression of outcome-selective Pavlovian-to-instrumental transfer

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          Abstract

          Although several studies have examined the subcortical circuitry underlying Pavlovian-to-instrumental transfer (PIT), the role of medial prefrontal cortex in this behavior is largely unknown. Elucidating the cortical contributions to PIT will be key for understanding how reward-paired cues control behavior in both adaptive and maladaptive context (i.e., addiction). Here we use bilateral lesions in a rat model to show that infralimbic prefrontal cortex (ilPFC) is necessary for appropriate expression of PIT. Further, we show that ilPFC mediates this effect via functional connectivity with nucleus accumbens shell (NAcS). Together, these data provide the first demonstration that a specific cortico-striatal circuit is necessary for cue-invigorated reward seeking during specific PIT.

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          Author and article information

          Journal
          Learn Mem
          Learn. Mem
          learnmem
          Learning & Memory
          Cold Spring Harbor Laboratory Press
          1072-0502
          1549-5485
          October 2015
          : 22
          : 10
          : 509-513
          Affiliations
          [1 ]Department of Psychiatry, Division of Molecular Psychiatry, New Haven, Connecticut 06520, USA
          [2 ]Department of Psychology, Yale University, New Haven, Connecticut 06520, USA
          [3 ]Interdepartmental Neuroscience Program, Yale University, New Haven, Connecticut 06520, USA
          Author notes
          Corresponding author: jane.taylor@ 123456yale.edu
          [4]

          Present address: Department of Neurosciences, Medical University of South Carolina, Charleston, SC 29425, USA.

          Article
          PMC4579356 PMC4579356 4579356 KeistlerLM038810
          10.1101/lm.038810.115
          4579356
          26373829
          © 2015 Keistler et al.; Published by Cold Spring Harbor Laboratory Press

          This article is distributed exclusively by Cold Spring Harbor Laboratory Press for the first 12 months after the full-issue publication date (see http://learnmem.cshlp.org/site/misc/terms.xhtml). After 12 months, it is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at http://creativecommons.org/licenses/by-nc/4.0/.

          Funding
          Funded by: PHS
          Award ID: P50 AA012870
          Award ID: RO1 DA011717
          Funded by: CT Department of Mental Health
          Categories
          Brief Communication

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