Blog
About

0
views
0
recommends
+1 Recommend
1 collections
    0
    shares
      • Record: found
      • Abstract: found
      • Article: found

      Failure of Free Fatty Acids to Influence Myocardial Oxygen Consumption in the Intact, Anesthetized Dog

      , , ,

      Cardiology

      S. Karger AG

      Coronary blood flow, Myocardial metabolism

      Read this article at

      ScienceOpenPublisherPubMed
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          Myocardial oxygen consumption (MyO<sub>2</sub>) was measured in intact, anesthetized dogs prior to and during an acute elevation of arterial free fatty acids (FFA). FFA were elevated by the infusion of a lipid emulsion (‘Intralipid’) coupled with heparin to intensify lipolysis. Intralipid infusion prior to heparin (n = 7) caused a small increase in FFA (352 ± 41–666 ± 67 µEq/l) without significant change in either MyO<sub>2</sub> or hemodynamics. Following heparin, arterial FFA rose from a base line, preheparin level of 649 ± 50–1,925 ± 186 µEq/l at 10 min, 1,988 ± 247 µ Eq/l at 20 min, and 1,750 ± 221 µ./Eq/l at 30 min. Hemodynamics were essentially stable throughout the study. No significant change was observed in either MyO<sub>2</sub> or mean coronary blood flow, while myocardial oxygen extraction showed a small but significant increase at 10 and 30 min. An acute elevation of arterial FFA within the physiologic range does not significantly affect myocardial oxygen consumption in the intact, closed-chest anesthetized dog.

          Related collections

          Author and article information

          Journal
          CRD
          Cardiology
          10.1159/issn.0008-6312
          Cardiology
          S. Karger AG
          0008-6312
          1421-9751
          1973
          1973
          29 October 2008
          : 58
          : 4
          : 220-228
          Affiliations
          Cardiovascular Research Section, Department of Medicine, Rhode Island Hospital, and Division of Biological and Medical Sciences, Brown University, Providence, R.I.
          Article
          169637 Cardiology 1973;58:220–228
          10.1159/000169637
          4274108
          © 1973 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          Page count
          Pages: 9
          Categories
          Paper

          Comments

          Comment on this article