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      Implantable Device Related Infection

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      Shock (Augusta, Ga.)

      Biofilm, CLABSI, CAUTI, nosocomial infection

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          Abstract

          Over half of the nearly 2 million healthcare-associated infections can be attributed to indwelling medical devices. In this review we highlight the difficulty in diagnosing implantable device related infection and how this leads to a likely underestimate of the prevalence. We then provide a length-scale conceptualization of device related infection pathogenesis. Within this conceptualization we focus specifically on biofilm formation and the role of host immune and coagulation systems. Using this framework, we describe how current and developing preventative strategies target specific processes along the entire length-scale. In light of the significant time horizon for the development and translation of new preventative technologies, we also emphasize the need for parallel development of in situ treatment strategies. Specific examples of both preventative and treatment strategies and how they align with the length-scale conceptualization are described.

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          Author and article information

          Journal
          9421564
          8584
          Shock
          Shock
          Shock (Augusta, Ga.)
          1073-2322
          1540-0514
          15 July 2016
          December 2016
          01 December 2017
          : 46
          : 6
          : 597-608
          Affiliations
          Department of Emergency Medicine, Michigan Center for Integrative Research in Critical Care, Biointerfaces Institute, University of Michigan
          Author notes
          Corresponding Author: J. Scott VanEpps, University of Michigan, Department of Emergency Medicine, NCRC Building 26, Room 327N, 2800 Plymouth Rd, Ann Arbor, MI 48109, Phone (734) 763-2702, Fax (734) 763-9389, jvane@ 123456med.umich.edu

          COI: JGY is currently co-founder and chief technology officer of Akadeum Life Sciences, Inc.

          Article
          PMC5110396 PMC5110396 5110396 nihpa802134
          10.1097/SHK.0000000000000692
          5110396
          27454373
          Categories
          Article

          Biofilm, nosocomial infection, CAUTI, CLABSI

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