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      Biochemical Characterization of a Digitalis-Like Substance in Human Urine, Partially Purified by High Pressure Liquid Chromatography

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          Abstract

          We have partially purified a digitalis-like extract from human urine by means of high pressure liquid chromatography (HPLC). Four fractions, giving positive activity for the cross-reaction in the digoxin radioimmunoassay, Na-K-ATPase inhibition or competition with ouabain binding to its receptor, were detected on HPLC. Among these fractions, the first (F-l) was shown to contain the principle fraction, sharing all the activities, and to exhibit quite similar characteristics to ouabain in the modes of Na-K-ATPase inhibition, ouabain displacement activity and positive inotropic action.

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          Author and article information

          Journal
          CRD
          Cardiology
          10.1159/issn.0008-6312
          Cardiology
          S. Karger AG
          0008-6312
          1421-9751
          1989
          1989
          12 November 2008
          : 76
          : 6
          : 442-449
          Affiliations
          Second Department of Internal Medicine, School of Medicine, Kanazawa University, Kanazawa, Japan
          Article
          174531 Cardiology 1989;76:442–449
          10.1159/000174531
          2558793
          © 1989 S. Karger AG, Basel

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          Pages: 8
          Categories
          Original Paper

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