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      Biodegradable Materials for Bone Repair and Tissue Engineering Applications

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          Abstract

          This review discusses and summarizes the recent developments and advances in the use of biodegradable materials for bone repair purposes. The choice between using degradable and non-degradable devices for orthopedic and maxillofacial applications must be carefully weighed. Traditional biodegradable devices for osteosynthesis have been successful in low or mild load bearing applications. However, continuing research and recent developments in the field of material science has resulted in development of biomaterials with improved strength and mechanical properties. For this purpose, biodegradable materials, including polymers, ceramics and magnesium alloys have attracted much attention for osteologic repair and applications. The next generation of biodegradable materials would benefit from recent knowledge gained regarding cell material interactions, with better control of interfacing between the material and the surrounding bone tissue. The next generations of biodegradable materials for bone repair and regeneration applications require better control of interfacing between the material and the surrounding bone tissue. Also, the mechanical properties and degradation/resorption profiles of these materials require further improvement to broaden their use and achieve better clinical results.

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          Most cited references 429

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                Author and article information

                Contributors
                Role: Academic Editor
                Journal
                Materials (Basel)
                Materials (Basel)
                materials
                Materials
                MDPI
                1996-1944
                31 August 2015
                September 2015
                : 8
                : 9
                : 5744-5794
                Affiliations
                [1 ]Faculty of Dentistry, Matrix Dynamics Group, University of Toronto, 150 College Street, Toronto, ON M5S 3E2, Canada
                [2 ]School of Clinical Dentistry, University of Sheffield, Sheffield S10 2TN, UK; E-Mail: shariqnajeeb@ 123456gmail.com
                [3 ]School of Materials and Metallurgy, University of Birmingham, Birmingham B15 2TT, UK; E-Mail: drzohaibkhurshid@ 123456gmail.com
                [4 ]Biomaterials Department of Biomedical Engineering, School of Engineering, King Faisal University, Al-Hofuf 31982, Saudi Arabia
                [5 ]Faculty of Dentistry, Division of Biomedical Sciences, McGill University, 2001 McGill College Avenue, Montreal, QC H3A 1G1, Canada; E-Mail: vivek.verma@ 123456mail.mcgill.ca
                [6 ]College of Dentistry, Division of Prosthodontics, Ziauddin University, 4/B, Clifton, Karachi 7550, Pakistan; E-Mail: drh.rashid@ 123456hotmail.com
                [7 ]Matrix Dynamics Group, Faculty of Dentistry, University of Toronto, 150 College Street, Toronto, ON M5S 3E2, Canada; E-Mail: Michael.Glogauer@ 123456utoronto.ca
                Author notes
                [* ]Author to whom correspondence should be addressed; E-Mail: zeeshan.sheikh@ 123456utoronto.ca ; Tel.: +1-514-224-7490.
                Article
                materials-08-05273
                10.3390/ma8095273
                5512653
                © 2015 by the authors.

                Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license ( http://creativecommons.org/licenses/by/4.0/).

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