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      Brain Network Analysis and Classification Based on Convolutional Neural Network

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          Abstract

          Background: Convolution neural networks (CNN) is increasingly used in computer science and finds more and more applications in different fields. However, analyzing brain network with CNN is not trivial, due to the non-Euclidean characteristics of brain network built by graph theory.

          Method: To address this problem, we used a famous algorithm “word2vec” from the field of natural language processing (NLP), to represent the vertexes of graph in the node embedding space, and transform the brain network into images, which can bridge the gap between brain network and CNN. Using this model, we analyze and classify the brain network from Magnetoencephalography (MEG) data into two categories: normal controls and patients with migraine.

          Results: In the experiments, we applied our method on the clinical MEG dataset, and got the mean classification accuracy rate 81.25%.

          Conclusions: These results indicate that our method can feasibly analyze and classify the brain network, and all the abundant resources of CNN can be used on the analysis of brain network.

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          Most cited references27

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          Deep Residual Learning for Image Recognition

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            Emergence of scaling in random networks

            Systems as diverse as genetic networks or the world wide web are best described as networks with complex topology. A common property of many large networks is that the vertex connectivities follow a scale-free power-law distribution. This feature is found to be a consequence of the two generic mechanisms that networks expand continuously by the addition of new vertices, and new vertices attach preferentially to already well connected sites. A model based on these two ingredients reproduces the observed stationary scale-free distributions, indicating that the development of large networks is governed by robust self-organizing phenomena that go beyond the particulars of the individual systems.
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              The structure and function of complex networks

              M. Newman (2003)
              Inspired by empirical studies of networked systems such as the Internet, social networks, and biological networks, researchers have in recent years developed a variety of techniques and models to help us understand or predict the behavior of these systems. Here we review developments in this field, including such concepts as the small-world effect, degree distributions, clustering, network correlations, random graph models, models of network growth and preferential attachment, and dynamical processes taking place on networks.
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                Author and article information

                Contributors
                Journal
                Front Comput Neurosci
                Front Comput Neurosci
                Front. Comput. Neurosci.
                Frontiers in Computational Neuroscience
                Frontiers Media S.A.
                1662-5188
                10 December 2018
                2018
                : 12
                : 95
                Affiliations
                [1] 1College of Information Science and Engineering, Northeastern University , Shenyang, China
                [2] 2Department of Neurology, Cincinnati Children's Hospital Medical Center , Cincinnati, OH, United States
                Author notes

                Edited by: Dan Chen, Wuhan University, China

                Reviewed by: Baiying Lei, Shenzhen University, China; Gang Li, University of North Carolina at Chapel Hill, United States

                *Correspondence: Lu Meng menglu1982@ 123456gmail.com
                Article
                10.3389/fncom.2018.00095
                6295646
                30618690
                c043a560-730a-416c-b0e0-39dea863d580
                Copyright © 2018 Meng and Xiang.

                This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

                History
                : 22 February 2018
                : 19 November 2018
                Page count
                Figures: 12, Tables: 6, Equations: 4, References: 41, Pages: 12, Words: 6299
                Funding
                Funded by: National Natural Science Foundation of China 10.13039/501100001809
                Award ID: 61101057
                Funded by: Foundation for the National Institutes of Health 10.13039/100000009
                Award ID: R21NS072817
                Funded by: National Institute of Neurological Disorders and Stroke 10.13039/100000065
                Award ID: 1R21NS081420
                Categories
                Neuroscience
                Original Research

                Neurosciences
                convolution neural networks,brain network,word2vec,node embedding space,meg
                Neurosciences
                convolution neural networks, brain network, word2vec, node embedding space, meg

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