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      Malignant nodular hidradenoma of scalp

      case-report

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          Abstract

          Malignant nodular hidradenoma (MNH) is a rare tumor of sweat gland known by many names in the literature. Scalp is a known and yet uncommon site of occurrence. We describe two patients with scalp MNH with brain parenchymal invasion. Both tumors recurred in spite of total excision and radiotherapy.

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          Most cited references10

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          Clearcell hidradenoma; report of three cases with widespread metastases.

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            Atypical and malignant hidradenomas: a histological and immunohistochemical study

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              Hidradenocarcinoma: a histological and immunohistochemical study.

              The diagnosis of hidradenocarcinoma is difficult due to a combination of factors including inconsistent nomenclature/ classification, rarity of the neoplasm, and variable morphology of cells composing the neoplasm. Immunohistochemistry has not been previously performed on a series of hidradenocarcinomas. We evaluated six cases of hidradenocarcinoma histologically and immunohistochemically using antibodies to gross cystic disease fluid protein-15 (GCDFP-15), carcino-embryonic antigen (CEA), epithelial membrane antigen (EMA), S-100 protein, keratin AE1/3, cytokeratin 5/6, p53, bcl-1, bcl-2, and Ki67. Histology suggested concurrent eccrine and apocrine differentiation of the cases. Ki67 and p53 staining was strongly positive in five of six tumors. The neoplasms stained with antibodies to CEA, S-100 protein, GCDFP-15, EMA, bcl-1, and bcl-2 in no consistent pattern. All tumors studied stained positively for keratin AE1/3 and cytokeratin 5/6. In making the diagnosis of hidradenocarcinoma, it may be unnecessary to separate hidradenocarcinoma into eccrine and apocrine categories, and although Ki67 and p53 may be helpful, histological parameters remain paramount.
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                Author and article information

                Journal
                J Neurosci Rural Pract
                J Neurosci Rural Pract
                JNRP
                Journal of Neurosciences in Rural Practice
                Medknow Publications & Media Pvt Ltd (India )
                0976-3147
                0976-3155
                Oct-Dec 2014
                : 5
                : 4
                : 423-425
                Affiliations
                [1] Department of Neurosurgery, Rahman Hospital, Guwahati, Assam, India
                [1 ] Department of Neurosurgery, National Institute of Mental Health and Neurosciences, Bangalore, Karnataka, India
                [2 ] Department of Neuropathology, National Institute of Mental Health and Neurosciences, Bangalore, Karnataka, India
                Author notes
                Address for correspondence: Dr. Dhaval Shukla, Department of Neurosurgery, National Institute of Mental Health and Neurosciences, Bangalore - 560 029, Karnataka, India. E-mail: neurodhaval@ 123456rediffmail.com
                Article
                JNRP-5-423
                10.4103/0976-3147.140011
                4173251
                c070d568-6fa3-4e4e-9604-4644b76337b1
                Copyright: © Journal of Neurosciences in Rural Practice

                This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

                History
                Categories
                Case Report

                Neurosciences
                cutaneous adnexal tumor,malignant nodular hidradenoma,scalp tumor,skull tumor
                Neurosciences
                cutaneous adnexal tumor, malignant nodular hidradenoma, scalp tumor, skull tumor

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