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      10 Years of GWAS Discovery: Biology, Function, and Translation

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          Abstract

          Application of the experimental design of genome-wide association studies (GWASs) is now 10 years old (young), and here we review the remarkable range of discoveries it has facilitated in population and complex-trait genetics, the biology of diseases, and translation toward new therapeutics. We predict the likely discoveries in the next 10 years, when GWASs will be based on millions of samples with array data imputed to a large fully sequenced reference panel and on hundreds of thousands of samples with whole-genome sequencing data.

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          Author and article information

          Contributors
          Journal
          Am J Hum Genet
          Am. J. Hum. Genet
          American Journal of Human Genetics
          Elsevier
          0002-9297
          1537-6605
          06 July 2017
          06 July 2017
          : 101
          : 1
          : 5-22
          Affiliations
          [1 ]Institute for Molecular Bioscience, University of Queensland, Brisbane, QLD 4072, Australia
          [2 ]Queensland Brain Institute, University of Queensland, Brisbane, QLD 4072, Australia
          [3 ]Departments of Genetics and Genomic Sciences and Psychiatry, Icahn School of Medicine at Mount Sinai, NY, NY 10029, USA
          [4 ]Oxford Centre for Diabetes, Endocrinology, and Metabolism, University of Oxford, Churchill Hospital, Old Road, Headington, Oxford OX3 7LJ, UK
          [5 ]Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, UK
          [6 ]Oxford NIHR Biomedical Research Centre, Churchill Hospital, Old Road, Headington, Oxford OX3 7LJ, UK
          [7 ]Institute of Health and Biomedical Innovation, Queensland University of Technology, Translational Research Institute, Princess Alexandra Hospital, Brisbane, QLD 4102, Australia
          Author notes
          []Corresponding author peter.visscher@ 123456uq.edu.au
          Article
          PMC5501872 PMC5501872 5501872 S0002-9297(17)30240-9
          10.1016/j.ajhg.2017.06.005
          5501872
          28686856
          c080042a-b4df-4506-ac17-05c84e481131
          © 2017 American Society of Human Genetics.
          History
          Categories
          Review

          genome-wide association study,SNP,schizophrenia,obesity,auto-immune disease,heritability

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