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      10 Years of GWAS Discovery: Biology, Function, and Translation

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          Abstract

          Application of the experimental design of genome-wide association studies (GWASs) is now 10 years old (young), and here we review the remarkable range of discoveries it has facilitated in population and complex-trait genetics, the biology of diseases, and translation toward new therapeutics. We predict the likely discoveries in the next 10 years, when GWASs will be based on millions of samples with array data imputed to a large fully sequenced reference panel and on hundreds of thousands of samples with whole-genome sequencing data.

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          Author and article information

          Contributors
          Peter M. Visscher
          Journal
          Journal ID (nlm-ta): Am J Hum Genet
          Journal ID (iso-abbrev): Am. J. Hum. Genet
          Title: American Journal of Human Genetics
          Publisher: Elsevier
          ISSN (Print): 0002-9297
          ISSN (Electronic): 1537-6605
          Publication date (Print): 06 July 2017
          Publication date (Electronic): 06 July 2017
          Volume: 101
          Issue: 1
          Pages: 5-22
          Affiliations
          [1 ]Institute for Molecular Bioscience, University of Queensland, Brisbane, QLD 4072, Australia
          [2 ]Queensland Brain Institute, University of Queensland, Brisbane, QLD 4072, Australia
          [3 ]Departments of Genetics and Genomic Sciences and Psychiatry, Icahn School of Medicine at Mount Sinai, NY, NY 10029, USA
          [4 ]Oxford Centre for Diabetes, Endocrinology, and Metabolism, University of Oxford, Churchill Hospital, Old Road, Headington, Oxford OX3 7LJ, UK
          [5 ]Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, UK
          [6 ]Oxford NIHR Biomedical Research Centre, Churchill Hospital, Old Road, Headington, Oxford OX3 7LJ, UK
          [7 ]Institute of Health and Biomedical Innovation, Queensland University of Technology, Translational Research Institute, Princess Alexandra Hospital, Brisbane, QLD 4102, Australia
          Author notes
          [∗ ]Corresponding author peter.visscher@ 123456uq.edu.au
          Article
          Accession ID: PMC5501872 Pmcid ID: PMC5501872 Pmc-uid ID: 5501872 Publisher ID: S0002-9297(17)30240-9
          DOI: 10.1016/j.ajhg.2017.06.005
          PMC ID: 5501872
          PubMed ID: 28686856
          SO-VID: c080042a-b4df-4506-ac17-05c84e481131
          Copyright © © 2017 American Society of Human Genetics.
          History
          Categories
          Subject: Review

          Keywords: genome-wide association study,SNP,schizophrenia,obesity,auto-immune disease,heritability
          Data availability:
          Keywords: genome-wide association study, SNP, schizophrenia, obesity, auto-immune disease, heritability

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