98
views
0
recommends
+1 Recommend
0 collections
    0
    shares
      • Record: found
      • Abstract: found
      • Article: found
      Is Open Access

      Lactobacillus Adhesion to Mucus

      review-article
      1 , 1 , 2 , *
      Nutrients
      MDPI
      adhesion, binding, mucin, mucus, MUC2, lactobacillus, MucBP, probiotics

      Read this article at

      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          Mucus provides protective functions in the gastrointestinal tract and plays an important role in the adhesion of microorganisms to host surfaces. Mucin glycoproteins polymerize, forming a framework to which certain microbial populations can adhere, including probiotic Lactobacillus species. Numerous mechanisms for adhesion to mucus have been discovered in lactobacilli, including partially characterized mucus binding proteins. These mechanisms vary in importance with the in vitro models studied, which could significantly affect the perceived probiotic potential of the organisms. Understanding the nature of mucus-microbe interactions could be the key to elucidating the mechanisms of probiotic adhesion within the host.

          Related collections

          Most cited references138

          • Record: found
          • Abstract: found
          • Article: found
          Is Open Access

          The Universal Protein Resource (UniProt) in 2010

          The primary mission of UniProt is to support biological research by maintaining a stable, comprehensive, fully classified, richly and accurately annotated protein sequence knowledgebase, with extensive cross-references and querying interfaces freely accessible to the scientific community. UniProt is produced by the UniProt Consortium which consists of groups from the European Bioinformatics Institute (EBI), the Swiss Institute of Bioinformatics (SIB) and the Protein Information Resource (PIR). UniProt is comprised of four major components, each optimized for different uses: the UniProt Archive, the UniProt Knowledgebase, the UniProt Reference Clusters and the UniProt Metagenomic and Environmental Sequence Database. UniProt is updated and distributed every 3 weeks and can be accessed online for searches or download at http://www.uniprot.org.
            Bookmark
            • Record: found
            • Abstract: found
            • Article: not found

            Mucins in the mucosal barrier to infection

            The mucosal tissues of the gastrointestinal, respiratory, reproductive, and urinary tracts, and the surface of the eye present an enormous surface area to the exterior environment. All of these tissues are covered with resident microbial flora, which vary considerably in composition and complexity. Mucosal tissues represent the site of infection or route of access for the majority of viruses, bacteria, yeast, protozoa, and multicellular parasites that cause human disease. Mucin glycoproteins are secreted in large quantities by mucosal epithelia, and cell surface mucins are a prominent feature of the apical glycocalyx of all mucosal epithelia. In this review, we highlight the central role played by mucins in accommodating the resident commensal flora and limiting infectious disease, interplay between underlying innate and adaptive immunity and mucins, and the strategies used by successful mucosal pathogens to subvert or avoid the mucin barrier, with a particular focus on bacteria. Supplementary information The online version of this article (doi:10.1038/mi.2008.5) contains supplementary material, which is available to authorized users.
              Bookmark
              • Record: found
              • Abstract: found
              • Article: not found

              Microbial modulation of innate defense: goblet cells and the intestinal mucus layer.

              The gastrointestinal epithelium is covered by a protective mucus gel composed predominantly of mucin glycoproteins that are synthesized and secreted by goblet cells. Changes in goblet cell functions and in the chemical composition of intestinal mucus are detected in response to a broad range of luminal insults, including alterations of the normal microbiota. However, the regulatory networks that mediate goblet cell responses to intestinal insults are poorly defined. The present review summarizes the results of developmental, gnotobiotic, and in vitro studies that showed alterations in mucin gene expression, mucus composition, or mucus secretion in response to intestinal microbes or host-derived inflammatory mediators. The dynamic nature of the mucus layer is shown. Available data indicate that intestinal microbes may affect goblet cell dynamics and the mucus layer directly via the local release of bioactive factors or indirectly via activation of host immune cells. A precise definition of the regulatory networks that interface with goblet cells may have broad biomedical applications because mucus alterations appear to characterize most diseases of mucosal tissues.
                Bookmark

                Author and article information

                Journal
                Nutrients
                nutrients
                Nutrients
                MDPI
                2072-6643
                20 May 2011
                May 2011
                : 3
                : 5
                : 613-636
                Affiliations
                [1 ] Department of Food Science and Human Nutrition, University of Illinois, 905 S. Goodwin Ave., Urbana, IL 61801, USA; Email: vantass2@ 123456illinois.edu
                [2 ] Division of Nutritional Sciences, University of Illinois, 905 S. Goodwin Ave., Urbana, IL 61801, USA
                Author notes
                [* ] Author to whom correspondence should be addressed; Email: mille216@ 123456illinois.edu ; Tel.: +1-217-244-1973.
                Article
                nutrients-03-00613
                10.3390/nu3050613
                3257693
                22254114
                c084f3d6-cbdf-4f02-91da-6feb71900833
                © 2011 by the authors; licensee MDPI, Basel, Switzerland.

                This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license ( http://creativecommons.org/licenses/by/3.0/).

                History
                : 10 April 2011
                : 05 May 2011
                : 11 May 2011
                Categories
                Review

                Nutrition & Dietetics
                probiotics ,binding,lactobacillus,mucus,mucin,muc2, adhesion,mucbp
                Nutrition & Dietetics
                probiotics , binding, lactobacillus, mucus, mucin, muc2, adhesion, mucbp

                Comments

                Comment on this article