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      Pediatric cancer epigenome and the influence of folate.

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          Abstract

          Despite improvement in clinical treatment of childhood cancer, it remains the leading cause of disease-related mortality in children with survivors often suffering from treatment-related toxicity and premature death. Because childhood cancer is vastly different from cancer in adults, a thorough understanding of the underlying molecular mechanisms specific to childhood cancer is essential. Although childhood cancer contains much fewer mutations, a subset of cancer subtypes has a higher frequency of mutations in gene encoding epigenetic regulators. Thus, in this review, we will focus on epigenetic deregulations in childhood cancers, the use of genome-wide analysis for cancer subtype classification, prediction of clinical outcomes and the influence of folate on epigenetic mechanisms.

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          Author and article information

          Journal
          Epigenomics
          Epigenomics
          Future Medicine Ltd
          1750-192X
          1750-192X
          2015
          : 7
          : 6
          Affiliations
          [1 ] Department of Pediatrics, Texas Children's Cancer Center, 6701 Fannin St, Ste 1400, Houston, TX 77030, USA.
          [2 ] Dan L Duncan Cancer Center, 1 Baylor Plaza 450A, Houston, TX 77030, USA.
          [3 ] Department of Molecular & Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA.
          Article
          NIHMS699025
          10.2217/epi.15.42
          4636966
          25950259
          c08bd5c9-6cf7-49a6-91e4-0fd9596fa09f
          History

          histone modifications,therapeutics,cancer prevention,DNA methylation,childhood cancer,epigenetics,folate

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