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      Effect of the extracts and fractions of Baccharis trimera and Syzygium cumini on glycaemia of diabetic and non-diabetic mice.

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          Abstract

          In the present study, we investigated the effects of extracts and fractions of Baccharis trimera and Syzygium cumini on glycaemia of diabetic and non-diabetic mice. Crude ethanolic extracts and aqueous and butanolic fractions of the aerial parts of Baccharis trimera and leaves of Syzygium cumini were evaluated. None of the extracts or fractions (200 or 2000 mg/kg, per os) induced any effect after acute administration. Seven-day treatment with crude ethanolic and aqueous and butanolic fractions (200-2000 mg/kg, twice daily, per os) of Syzygium cumini reduced glycaemia of non-diabetic mice. However, this effect was associated with a reduction of food intake and body weight, indicating that this may not be a genuine hypoglycaemic effect. In diabetic mice, only the aqueous fraction of Baccharis trimera (2000 mg/kg, twice daily, per os) reduced the glycaemia after a 7-day treatment. This effect was not associated with a body weight reduction. The results suggest that Baccharis trimera presents a potential antidiabetic activity and indicate that food intake and body weight must be determined when evaluating metabolic parameters after prolonged administration of plant extracts.

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          Author and article information

          Journal
          J Ethnopharmacol
          Journal of ethnopharmacology
          Elsevier BV
          0378-8741
          0378-8741
          Dec 01 2005
          : 102
          : 3
          Affiliations
          [1 ] Faculty of Pharmacy, Federal University of Minas Gerais, Belo Horizonte MG, Brazil.
          Article
          S0378-8741(05)00416-2
          10.1016/j.jep.2005.06.025
          16055289
          c08fe9a4-876a-461b-abbf-97973b1a8d2b
          History

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