Plasma potassium ranges associated with mortality across stages of chronic kidney disease: the Stockholm CREAtinine Measurements (SCREAM) project

Abstract

Background

Small-scale studies suggest that hyperkalaemia is a less threatening condition in chronic kidney disease (CKD), arguing adaptation/tolerance to potassium (K ⁺) retention. This study formally evaluates this hypothesis by estimating the distribution of plasma K ⁺ and its association with mortality across CKD stages.

Methods

This observational study included all patients undergoing plasma K ⁺ testing in Stockholm during 2006–11. We randomly selected one K ⁺ measurement per patient and constructed a cross-sectional cohort with mortality follow-up. Covariates included demographics, comorbidities, medications and estimated glomerular filtration rate (eGFR). We estimated K ⁺ distribution and defined K ⁺ ranges associated with 90-, 180- and 365-day mortality.

Results

Included were 831 760 participants, of which 70 403 (8.5%) had CKD G3 (eGFR <60–30 mL/min) and 8594 (1.1%) had CKD G4–G5 (eGFR <30 mL/min). About 66 317 deaths occurred within a year. Adjusted plasma K ⁺ increased across worse CKD stages: from median 3.98 (95% confidence interval 3.49–4.59) for eGFR >90 to 4.43 (3.22–5.65) mmol/L for eGFR ≤15 mL/min/1.73 m ². The association between K ⁺ and mortality was U-shaped, but it flattened at lower eGFR strata and shifted upwards. For instance, the range where the 90-day mortality risk increased by no more than 100% was 3.45–4.94 mmol/L in eGFR >60 mL/min, but was 3.36–5.18  in G3 and 3.26–5.53 mmol/L in G4–G5. In conclusion, CKD stage modifies K ⁺ distribution and the ranges that predict mortality in the community.

Conclusion

Although this study supports the view that hyperkalaemia is better tolerated with worse CKD, it challenges the current use of a single optimal K ⁺ range for all patients.