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      Ketosis and brain handling of glutamate, glutamine, and GABA.

      Epilepsia
      Animals, Brain, metabolism, Glutamic Acid, Glutamine, Humans, Ketogenic Diet, Ketosis, gamma-Aminobutyric Acid

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          Abstract

          We hypothesize that one mechanism of the anti-epileptic effect of the ketogenic diet is to alter brain handling of glutamate. According to this formulation, in ketotic brain astrocyte metabolism is more active, resulting in enhanced conversion of glutamate to glutamine. This allows for: (a) more efficient removal of glutamate, the most important excitatory neurotransmitter; and (b) more efficient conversion of glutamine to GABA, the major inhibitory neurotransmitter.

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          Author and article information

          Journal
          19049594
          2722878
          10.1111/j.1528-1167.2008.01841.x

          Chemistry
          Animals,Brain,metabolism,Glutamic Acid,Glutamine,Humans,Ketogenic Diet,Ketosis,gamma-Aminobutyric Acid
          Chemistry
          Animals, Brain, metabolism, Glutamic Acid, Glutamine, Humans, Ketogenic Diet, Ketosis, gamma-Aminobutyric Acid

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