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Rifaximin Redux: Treatment of recurrent Clostridium difficile infections with Rifaximin immediately post-vancomycin treatment
Stuart Johnson ,
Christopher Schriever ,
Ursula Patel ,
Toral Patel ,
David W. Hecht ,
Dale N. Gerding
December 2009
December 2009
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Abstract
We report our continued experience with rifaximin as a post-vancomycin treatment strategy
in six patients with multiple recurrences of C. difficile infection (CDI). Four of
the six patients (67%) had no further diarrhea episodes, but two patients failed shortly
after or during the rifaximin treatment. C. difficile isolates from one of the two
patients who failed treatment had an MIC of >256 microg/ml to rifampin. Serial therapy
with vancomycin, followed by rifaximin remains an option for some patients with multiple
CDI recurrences.