Carnitine Palmitoyltransferase in Patients with Cardiac Ischemia due to Atherosclerotic Coronary Artery Disease and in Patients with Idiopathic Dilated Cardiomyopathy

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Abstract

Cardiac ischemia is associated with an impairment in long-chain fatty acid metabolism. We studied carnitine palmitoyltransferase (CPT) in left ventricular biopsies of 6 transplant recipients with ischemia due to atherosclerosis, 4 patients with dilated cardiomyopathy, and 5 donor hearts. Total CPT activity was not significantly different between the three groups (7.9 ± 3; 6.7 ± 2, and 8 ± 3 nmol/min/mg noncollagenous protein). Residual CPT activity after inhibition by malonyl-CoA (0.4 mM) was 38 ± 11, 36 ± 5 and 38 ± 7%. There were no differences in IC<sub>50</sub> values. Residual CPT activity after the addition of the detergent Triton X-100 (0.5%) was 58 ± 17, 54 ± 2 and 50 ± 8% (nonsignificant). Our results suggest that (i) total CPT activity and (ii) the sensitivity of the interaction of CPT I with its regulator malonyl-CoA are not affected by cardiac ischemia, and (iii) the ratio of CPT I to CPT II is not altered in cardiac ischemia.

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Author and article information

Journal

Journal ID (publisher-id): CRD

Journal ID (nlm-ta): Cardiology

Journal ID (doi): 10.1159/issn.0008-6312

Title: Cardiology

Publisher: S. Karger AG

ISSN (Print): 0008-6312

ISSN (Electronic): 1421-9751

Publication date Subscription-year: 1997

Publication date (Print): 1997

Publication date (Electronic): 19 November 2008

Volume: 88

Issue: 3

Pages: 258-263

Affiliations

Departments of Neurology, ^aFriedrich Wilhelm University, Bonn, and ^bMartin Luther University, Halle-Wittenberg, Germany

Article

Publisher ID: 177340 Other ID: Cardiology 1997;88:258–263

DOI: 10.1159/000177340

PubMed ID: 9129847

SO-VID: c0da1dd9-558e-4c8e-999c-0e15f579c7d4

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Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

History

Date received : 22 September 1995

Date accepted : 03 May 1996

Page count

Pages: 6

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