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Pentylenetetrazole kindling impairs long-term memory in rats
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Abstract
The effect of pentylenetetrazole (PTZ) kindling on learning and retention in active
(shuttle-box) and passive (step-down) avoidance was studied in rats. PTZ kindling
did not impair learning and significantly disturbed long-term memory estimated from
retention tests, i.e. PTZ kindling induced a retrograde amnesia in the active and
passive avoidance situations. The present results support the view that memory deficit
is an integral part of epilepsy.