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      Efficacy of Artemether combined with Compound Dihydroartemisinin Tablets for uncomplicated malaria cases in peacekeeping mission

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          Abstract

          Objective To assess the therapeutic efficacy and safety of Artemether combined with Compound Dihydroartemisinin Tablets for uncomplicated malaria in peacekeeping mission in the Democratic Republic of the Congo.

          Methods The clinical data of 56 patients with uncomplicated malaria in Chines Level II Hospital in MONUSCO from September 2018 to September 2019 were retrospectively analyzed. Artemether injection for antimalarial therapy was administered once the diagnosis was clear, then after 2 to 3 days,a course changed to Compound Dihydroartemisinin Tablets was given. The symptoms, body temperature, parasite densityand adverse effects were observed. The therapeutic efficacy was assessed through WHO classification of therapeutic response to antimalarial drugs.

          Results All cases showed the adequate clinical and parasitological responses, without severe adverse effect. There were 41 cases of pure Plasmodium falciparum (Pf) malaria and 15 cases of mixed malaria. The average fever clearance time (FCT) was (28.5±7.6) h for pure Pf malaria patients, and (26.4±6.5) h for mixed malaria patients. The average parasite clearance time (PCT) was (31.5±8.3) h for pure Pf malaria, and (30.4±6.7) h for mixed malaria patients. The average parasite clearance half-life (PC 1/2) was (2.54±0.55) h forpure Pf patients, and (2.42±0.43) h formixed malaria patients. There was no significant difference in fever resolution time, PCT and PC 1/2 between two groups ( P>0.05).

          Conclusion Artemether combined with Compound Dihydroartemisinin Tab lets was efficient and safe for the treatment of uncomplicated malaria cases in peacekeeping mission in the Democratic Republic of the Congo.

          Abstract

          摘要: 目的 评价蒿甲醚联合复方双氢青蒿素片对刚果 (金) 维和任务区非重症疟疾的临床疗效。 方法 回顾性分析刚果 (金) 中国二级医院2018年9月—2019年9月收治的维和任务区56例非重症疟疾患者的临床资料。患者明确诊断后即予“蒿甲醚注射液”肌肉注射治疗, 2~3 d后改为口服复方双氢青蒿素片。定期观察患者症状、体温、疟原虫密度和药物不良反应等指标。按WHO抗疟药物临床疗效分类综合评价治疗方案的疗效。 结果 56 例非重症疟疾患者中, 单纯恶性疟41例, 混合疟15例。全部患者均获得完全临床原虫治疗成功, 无严重不良反应发生。平均退热时间单纯恶性疟患者为 (28.5±7.6) h, 混合疟患者为 (26.4±6.5) h; 平均疟原虫清除时间单纯恶性疟患者为 (31.5±8.3) h, 混合疟患者为 (30.4±6.7) h; 平均疟原虫清除半衰期单纯恶性疟为 (2.54±0.55) h, 混合疟患者为 (2.42±0.43) h。两组患者退热时间、疟原虫清除时间及清除半衰期差异均无统计学意义 ( P>0.05) 。 结论 蒿甲醚联合复方双氢青蒿素片可有效治疗刚果 (金) 维和任务区非重症疟疾, 且安全性良好。

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          Author and article information

          Journal
          CTM
          China Tropical Medicine
          China Tropical Medicine (China )
          1009-9727
          01 June 2020
          01 June 2020
          : 20
          : 6
          : 565-568
          Affiliations
          1The 940th Hospital of Joint Logistics Support Force Army of PLA, Lanzhou, Gansu 730050, China
          2Chinese Level II Hospital of the United Nations Organization Stabilization Mission in the Democratic Republic of the Congo (MONUSCO), Bukavu, the Democratic Republic of the Congo
          Author notes
          Corresponding author: LIU Rui, E-mail: 937588763@ 123456qq.com
          Article
          j.cnki.46-1064/r.2020.06.17
          10.13604/j.cnki.46-1064/r.2020.06.17
          © 2020 Editorial Department of China Tropical Medicine

          This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 Unported License (CC BY-NC 4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. See https://creativecommons.org/licenses/by-nc/4.0/.

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