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      Intrapartum and neonatal mortality among low-risk women in midwife-led versus obstetrician-led care in the Amsterdam region of the Netherlands: a propensity score matched study

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          Abstract

          Objective

          To compare intrapartum and neonatal mortality in low-risk term women starting labour in midwife-led versus obstetrician-led care.

          Study design

          We performed a propensity score matched study using data from our national perinatal register, completed with data from medical files. We studied women without major risk factors with singleton pregnancies who gave birth at term between 2005 and 2008 in the Amsterdam region of the Netherlands. Major risk factors comprised non-vertex position of the fetus, previous Caesarean birth, hypertension, (gestational) diabetes mellitus, post-term pregnancy (≥42 weeks), prolonged rupture of membranes (>24 hours), vaginal bleeding in the second half of pregnancy or induced labour. Groups were devided by midwife-led versus obstetrician-led care at the onset of labour. The primary outcome was intrapartum and neonatal (<28 days) mortality. Secondary outcomes included obstetric interventions, 5 min Apgar scores<7 and neonatal intensive care admittance for >24 hours.

          Results

          We studied 57 396 women. Perinatal mortality occurred in 30 of 46 764 (0.64‰) women in midwife-led care and in 2 of 10 632 (0.19‰) women in obstetrician-led care (OR 3.4, 95% CI 0.82 to 14.3). A propensity score matched analysis in a 1:1 ratio with 10 632 women per group revealed an OR for perinatal mortality of 4.0 (95% CI 0.85 to 18.9).

          Conclusion

          Among low-risk women, midwife-led care at the onset of labour was associated with a statistically non-significant higher mortality rate.

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          Most cited references19

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            Methods for constructing and assessing propensity scores.

            To model the steps involved in preparing for and carrying out propensity score analyses by providing step-by-step guidance and Stata code applied to an empirical dataset.
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              Outcomes of planned home birth with registered midwife versus planned hospital birth with midwife or physician.

              Studies of planned home births attended by registered midwives have been limited by incomplete data, nonrepresentative sampling, inadequate statistical power and the inability to exclude unplanned home births. We compared the outcomes of planned home births attended by midwives with those of planned hospital births attended by midwives or physicians. We included all planned home births attended by registered midwives from Jan. 1, 2000, to Dec. 31, 2004, in British Columbia, Canada (n = 2889), and all planned hospital births meeting the eligibility requirements for home birth that were attended by the same cohort of midwives (n = 4752). We also included a matched sample of physician-attended planned hospital births (n = 5331). The primary outcome measure was perinatal mortality; secondary outcomes were obstetric interventions and adverse maternal and neonatal outcomes. The rate of perinatal death per 1000 births was 0.35 (95% confidence interval [CI] 0.00-1.03) in the group of planned home births; the rate in the group of planned hospital births was 0.57 (95% CI 0.00-1.43) among women attended by a midwife and 0.64 (95% CI 0.00-1.56) among those attended by a physician. Women in the planned home-birth group were significantly less likely than those who planned a midwife-attended hospital birth to have obstetric interventions (e.g., electronic fetal monitoring, relative risk [RR] 0.32, 95% CI 0.29-0.36; assisted vaginal delivery, RR 0.41, 95% 0.33-0.52) or adverse maternal outcomes (e.g., third- or fourth-degree perineal tear, RR 0.41, 95% CI 0.28-0.59; postpartum hemorrhage, RR 0.62, 95% CI 0.49-0.77). The findings were similar in the comparison with physician-assisted hospital births. Newborns in the home-birth group were less likely than those in the midwife-attended hospital-birth group to require resuscitation at birth (RR 0.23, 95% CI 0.14-0.37) or oxygen therapy beyond 24 hours (RR 0.37, 95% CI 0.24-0.59). The findings were similar in the comparison with newborns in the physician-assisted hospital births; in addition, newborns in the home-birth group were less likely to have meconium aspiration (RR 0.45, 95% CI 0.21-0.93) and more likely to be admitted to hospital or readmitted if born in hospital (RR 1.39, 95% CI 1.09-1.85). Planned home birth attended by a registered midwife was associated with very low and comparable rates of perinatal death and reduced rates of obstetric interventions and other adverse perinatal outcomes compared with planned hospital birth attended by a midwife or physician.
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                Author and article information

                Journal
                BMJ Open
                BMJ Open
                bmjopen
                bmjopen
                BMJ Open
                BMJ Publishing Group (BMA House, Tavistock Square, London, WC1H 9JR )
                2044-6055
                2018
                5 January 2018
                : 8
                : 1
                : e018845
                Affiliations
                [1 ] departmentDepartment of Obstetrics and Gynaecology , Academic Medical Center , Amsterdam, The Netherlands
                [2 ] departmentDepartment of Obstetrics and Gynaecology , Leiden University Medical Center , Leiden, The Netherlands
                [3 ] departmentDepartment of Medical Informatics , Academic Medical Center , Amsterdam, The Netherlands
                [4 ] departmentDepartment of Obstetrics and Gynaecology , VU University Medical Center , Amsterdam, The Netherlands
                [5 ] departmentNeonatal Intensive Care , Emma Children’s Hospital AMC , Amsterdam, The Netherlands
                [6 ] departmentSchool of Paediatrics and Reproductive Health , The Robinson Institute, University of Adelaide , Adelaide, South Australia, Australia
                [7 ] South Australian Health and Medical Research Institute , Adelaide, South Australia, Australia
                Author notes
                [Correspondence to ] Melanie M J Wiegerinck; m.m.wiegerinck@ 123456amc.uva.nl
                Article
                bmjopen-2017-018845
                10.1136/bmjopen-2017-018845
                5781008
                29306890
                c0f59cd4-4762-40d8-aa06-6eeed48e9b37
                © Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2018. All rights reserved. No commercial use is permitted unless otherwise expressly granted.

                This is an Open Access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/

                History
                : 29 July 2017
                : 25 September 2017
                : 20 November 2017
                Categories
                Obstetrics and Gynaecology
                Research
                1506
                Custom metadata
                unlocked

                Medicine
                midwifery,low risk,perinatal mortality,intrapartum mortality,neonatal mortality,home birth
                Medicine
                midwifery, low risk, perinatal mortality, intrapartum mortality, neonatal mortality, home birth

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