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      Binding of Methyltrienolone to Various Androgen-Dependent and Androgen-Responsive Tissues in Four Animal Species

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          Abstract

          Comparative sucrose gradient studies of the in vitro binding of dihydrotestosterone (DHT) and of a synthetic androgen, methyltrienolone (R 1881), have been done with the cytosols of various tissues of the rat, mouse, cock and man. With rat prostate cytosol, the amount of R 1881 and DHT binding in the 8–9S region of the gradient was found to be comparable. Specific 8-9S peaks of R 1881 were also found in rat levator ani/bulbocavernosus and skeletal muscles and in the mouse kidney. Only 4-5S peaks could be demonstrated in the cock’s comb while DHT under the same conditions showed both 8–9S and 4–5S binding. Binding of R 1881 to the cytosol of the hyperplasticprostate was polydispersed, and showed evidence of the presence of aggregates. Evidence was also found that R 1881 could bind to the progesterone receptor in rat uterus. Our study supports the theory that in a given species the androgen receptors are similar if not identical in all the tissues. The synthetic androgen R 1881 appears to be a useful tool for androgen receptor studies in various animal species provided that the tissue under study contains no progesterone receptor.

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          Author and article information

          Journal
          HRE
          Horm Res Paediatr
          10.1159/issn.1663-2818
          Hormone Research in Paediatrics
          S. Karger AG
          1663-2818
          1663-2826
          1976
          1976
          25 November 2008
          : 7
          : 6
          : 333-340
          Affiliations
          Laboratory of Endocrinology Metabolism, Le Centre Hospitalier de I’Université Laval, Quebec
          Article
          178747 Horm Res 1976;7:333–340
          10.1159/000178747
          1028725
          © 1976 S. Karger AG, Basel

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          Pages: 8
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