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      The use of gold nanoparticles to enhance radiotherapy in mice.

      1 , ,
      Physics in medicine and biology
      IOP Publishing

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          Abstract

          Mice bearing subcutaneous EMT-6 mammary carcinomas received a single intravenous injection of 1.9 nm diameter gold particles (up to 2.7 g Au/kg body weight), which elevated concentrations of gold to 7 mg Au/g in tumours. Tumour-to-normal-tissue gold concentration ratios remained approximately 8:1 during several minutes of 250 kVp x-ray therapy. One-year survival was 86% versus 20% with x-rays alone and 0% with gold alone. The increase in tumours safely ablated was dependent on the amount of gold injected. The gold nanoparticles were apparently non-toxic to mice and were largely cleared from the body through the kidneys. This novel use of small gold nanoparticles permitted achievement of the high metal content in tumours necessary for significant high-Z radioenhancement.

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          Author and article information

          Journal
          Phys Med Biol
          Physics in medicine and biology
          IOP Publishing
          0031-9155
          0031-9155
          Sep 21 2004
          : 49
          : 18
          Affiliations
          [1 ] Nanoprobes, Inc., 95 Horse Block Rd., Yaphank, NY 11980, USA. hainfeld@nanoprobes.com
          Article
          10.1088/0031-9155/49/18/n03
          15509078
          c11cfead-6b63-4c83-8b4b-8f0e2add70ae
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