DISC1-TSNAX and DAOA genes in major depression and citalopram efficacy.

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Abstract

Major depressive disorder (MDD) is a common disease with high morbidity and still unsatisfying treatment response. Both MDD pathogenesis and antidepressant effect are supposed to be strongly affected by genetic polymorphisms. Among promising candidate genes, distrupted in schizophrenia 1 (DISC1), translin-associated factor X (TSNAX) and D-amino acid oxidase activator (DAOA) were suggested since their regulator role in neurodevelopment, neuroplasticity and neurotransmission, and previous evidence of cross-involvement in major psychiatric diseases.

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Author and article information

Journal

Journal ID (iso-abbrev): J Affect Disord

Title: Journal of affective disorders

ISSN (Electronic): 1573-2517

ISSN (Print): 0165-0327

Publication date (Electronic): Oct 2014

Volume: 168

Affiliations

[1 ] Unitat d'Antropologia (Dep de Biologia Animal) Facultat de Biologia and Institut de Biomedicina, Universitat de Barcelona (IBUB), Barcelona, Spain; Centro de Investigaciones Biomédicas en Red de Salud Mental (CIBERSAM), Instituto de Salud Carlos III, Madrid, Spain.

[2 ] Department of Biomedical and NeuroMotor Sciences, University of Bologna, Bologna, Italy.

[3 ] Department of Biomedical and NeuroMotor Sciences, University of Bologna, Bologna, Italy. Electronic address: alessandro.serretti@unibo.it.

[4 ] Unitat d'Antropologia (Dep de Biologia Animal) Facultat de Biologia and Institut de Biomedicina, Universitat de Barcelona (IBUB), Barcelona, Spain.

[5 ] Centro de Investigaciones Biomédicas en Red de Salud Mental (CIBERSAM), Instituto de Salud Carlos III, Madrid, Spain; Centre de Salut Mental Esquerre de l´Eixample, Hospital Clínic i Provincial de Barcelona. Institut d'Investigació Biomèdica Agustí Pi i Sunyer (IDIBAPS), Barcelona, Spain.

Article

Publisher Item ID: S0165-0327(14)00416-9

DOI: 10.1016/j.jad.2014.06.048

PubMed ID: 25043320

SO-VID: c126f2ab-e796-43ed-954d-92733d8e3a30

History

Keywords: Antidepressant,DAOA,DISC1,Gene,Major depression,TSNAX

Data availability:

Keywords: Antidepressant, DAOA, DISC1, Gene, Major depression, TSNAX

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