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Detection of α-globin gene deletion and duplication using quantitative multiplex PCR of short fluorescent fragments.
Zong-Ping Mo
1 ,
Chang-Shun Yu ,
Ya-Juan Li ,
Wei-xi Cao ,
Zheng-Yu Zeng ,
Yi-Xin Zhan ,
Gui-ling Mo ,
Chaohui Hu ,
Wenli Feng
Dec 17 2011
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Abstract
The aim of this study was to establish a sensitive method that can detect the presence of not only the common but also the unusual or unknown α-globin gene deletions for screening of α-thalassemia. We used quantitative multiplex PCR of short fluorescent fragments (QMPSF) for the α-globin genes (HBA) to screen α-thalassemia deletions.