+1 Recommend
1 collections
      • Record: found
      • Abstract: found
      • Article: found

      Biochemical Indices of Catecholaminergic Neuronal Activity in the Median Eminence during the Estrous Cycle of the Rat

      Read this article at

          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.


          An attempt was made to correlate the changes in blood concentrations of prolactin and luteinizing hormone (LH) which occur during the estrous cycle of rats with changes in biochemical estimates of the activities of dopamine (DA)- and norepinephrine (NE)-containing neurons in the median eminence. The serum concentrations of prolactin and LH markedly increased on the afternoon and evening (16.00–24.00 h) of proestrus. The steady state concentrations of NE and DA in the median eminence did not change at any time during the estrous cycle, but the α-methyltyrosine-induced decline of NE was increased during the morning of proestrus (8.00–12.00 h) while the decline of DA was decreased (12.00 h). The rate of total catecholamine synthesis (dopa accumulation after a decarboxylase inhibitor) in the median eminence was not markedly altered at any time during the estrous cycle; the lack of change of dopa accumulation on proestrus may be due, in part, to opposing changes in the rates of amine synthesis in NE and DA neurons.

          Related collections

          Author and article information

          S. Karger AG
          26 March 2008
          : 32
          : 1
          : 24-27
          Department of Pharmacology and Toxicology, Michigan State University, East Lansing, Mich., USA
          123124 Neuroendocrinology 1981;32:24–27
          © 1981 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          Page count
          Pages: 4
          Original Paper


          Comment on this article