Distribution of HCG and Asialo-HCG in the Mouse: Quantitative and Radioautographic Studies

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Abstract

The distribution of 125I-labeled HCG and asialo-HCG after intravenous injection was studied quantitatively and by radioautography in the luteal, liver and kidney tissue of the mouse. It was found that the disappearance rate of HCG from the blood was markedly enhanced after desialylation. Simultaneously the uptake of radioactivity in the liver was increased and that in the luteal tissue was decreased. In radioautography 125I-HCG was localized exclusively over the Kupffer cells, whereas 125I-asialo-HCG showed labeling of the parenchymal cells. This difference in the cellular site for HCG and asialo-HCG indicates that two mechanisms are active in the liver for the glycoprotein inactivation. Minor differences in the molecular structure may influence the mechanism and site of the hormonal uptake. The kidneys were relatively less important in the uptake of HCG and asialo-HCG, but they appeared to be more involved in the disposal of LH and FSH from the blood.

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Journal ID (publisher-id): HRE

Journal ID (nlm-ta): Horm Res Paediatr

Journal ID (doi): 10.1159/issn.1663-2818

Title: Hormone Research in Paediatrics

Publisher: S. Karger AG

ISSN (Print): 1663-2818

ISSN (Electronic): 1663-2826

Publication date Subscription-year: 1973

Publication date (Print): 1973

Publication date (Electronic): 21 November 2008

Volume: 4

Issue: 3

Pages: 177-189

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Department of Anatomy, University of Turku, Turku

Article

Publisher ID: 178306 Other ID: Horm Res 1973;4:177–189

DOI: 10.1159/000178306

PubMed ID: 4127111

SO-VID: c13f1e7c-b381-4a65-91f8-62678dad5f69

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Distribution of HCG and Asialo-HCG in the Mouse: Quantitative and Radioautographic Studies

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Karger: Endocrinology

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