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      Pre-Clinical Cushing’s Syndrome: Report of Three Cases and Literature Review

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          Pre-Cushing’s syndrome (PCS) is defined as an overproduction of cortisol by an adrenal adenoma, without physical changes on clinical examination. Three patients with PCS were recently diagnosed among 21 consecutive patients suffering from adrenal ‘incidentaloma’. All patients showed nonsuppression of serum and urinary cortisol following 2 and 8 mg of dexamethasone (DXM), and suppressed or normal baseline plasma ACTH. Unilateral uptake of radiolabelled iodocholesterol, which persisted after DXM, was uniformly present. The authors review 36 patients with PCS previously reported. This entity probably constitutes a transition from classic ‘nonfunctional’ adrenal adenoma to cortisol-producing adenoma. Uniform guidelines in the management of PCS cannot yet be given, but surgical intervention is usually required to prevent the development of long-term complications of subtle corticoid excess.

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          Author and article information

          Horm Res Paediatr
          Hormone Research in Paediatrics
          S. Karger AG
          05 December 2008
          : 41
          : 5-6
          : 230-235
          aDepartment of Endocrinology, Hospital ‘Dr. Josep Trueta’, Girona; bDepartment of Endocrinology, Hospital General Vail d’Hebró, Barcelona, Spain
          183930 Horm Res 1994;41:230–235
          © 1994 S. Karger AG, Basel

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          Page count
          Pages: 6
          Case Report and Review


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