Dual blockade of the PI3K/AKT/mTOR (AZD8055) and RAS/MEK/ERK (AZD6244) pathways synergistically inhibits rhabdomyosarcoma cell growth in vitro and in vivo.
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Abstract
To provide rationale for using phosphoinositide 3-kinase (PI3K) and/or mitogen-activated
protein kinase (MAPK) pathway inhibitors to treat rhabdomyosarcomas, a major cause
of pediatric and adolescent cancer deaths.
Title:
Clinical cancer research : an official journal of the American Association for Cancer
Research
Publisher:
American Association for Cancer Research (AACR)
ISSN
(Electronic):
1557-3265
ISSN
(Print):
1078-0432
Publication date
(Electronic):
Nov 01 2013
Volume: 19
Issue: 21
Affiliations
[1
]
Authors' Affiliations: Divisions of Clinical Studies, Cancer Therapeutics, and Molecular
Pathology, The Institute of Cancer Research, Sutton, Surrey; Histopathology Department,
The Royal Marsden Hospital NHS Foundation Trust, London, United Kingdom; and Department
of Neuropathology, University of Bonn, Bonn, Germany.