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      Anticuerpos anticitoplasma de neutrófilos (ANCA): una herramienta importante en el diagnóstico de las vasculitis Translated title: Antineutrophil cytoplasmic antibodies (ANCA): an important tool for the diagnosis of vasculitis

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          Abstract

          Se determinó la presencia de anticuerpos anticitoplasma de neutrófilos (ANCA) específicos para la proteinaza 3 (cANCA) y la mieloperoxidasa (pANCA) en 166 pacientes, 45 con vasculitis no precisadas y el resto con diferentes enfermedades asociadas con procesos inflamatorios, fenómenos autoinmune e infecciones, mediante inmunofluorescencia indirecta. Se detectó la presencia de cANCA en 12 casos con vasculitis, y pANCA en 8 pacientes con enfermedades autoinmunes y en 14 con anemia drepanocítica. Nuestros resultados sugieren la posibilidad de cierto grado de participación de estos autoanticuerpos en el daño del endotelio vascular que se observa en estas enfermedades, debido a la activación de los neutrófilos

          Translated abstract

          The presence of antineutrophil cytoplasmic antibody (ANCA) specific to proteinase 3(cANCA) and myeloperoxidase (pANCA) were determined by indirect immunofluoresce test in 166 patients, 45 of which presented with undetermined vasculitis and the rest with different diseases associated with inflammatory processes, autoimmune phenomena and infections. cANCA were detected in 12 cases with vasculitis whereas pANCA were observed in 8 patients with autoimmune diseases and in 14 with sickle cell anemia. Our results suggest the possibility of some level of involvement of these autoantibodies in the vascular endothelium damage that is observed in these diseases due to neutrophil activation

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          Author and article information

          Contributors
          Role: ND
          Role: ND
          Role: ND
          Role: ND
          Role: ND
          Journal
          hih
          Revista Cubana de Hematología, Inmunología y Hemoterapia
          Rev Cubana Hematol Inmunol Hemoter
          Editorial Ciencias Médicas (Ciudad de la Habana )
          1561-2996
          December 2002
          : 18
          : 3
          : 0
          Affiliations
          [1 ] Instituto de Hematología e Inmunología Cuba
          Article
          S0864-02892002000300006
          Product
          Product Information: website
          Categories
          HEMATOLOGY

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