3
views
0
recommends
+1 Recommend
0 collections
    0
    shares
      • Record: found
      • Abstract: found
      • Article: not found

      High expression of estrogen-related receptor α is significantly associated with poor prognosis in patients with colorectal cancer

      research-article

      Read this article at

      ScienceOpenPublisherPMC
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          Colorectal cancer (CRC) is one of the most common types of malignancy with high morbidity and mortality rates worldwide. This biologically heterogeneous disease results in diverse therapeutic responses, thus, novel prognostic biomarkers are required to improve CRC treatment. Estrogen-related receptor α (ERRα) is a nuclear orphan receptor, which is associated with estrogen receptor α. The present study aimed to investigate the expression of ERRα in patients with CRC, and explore the association between ERRα expression and clinicopathological factors, local recurrence and prognosis. In the present study, ERRα expression was detected in 15 fresh CRC tissues using quantitative real-time polymerase chain reaction (RT-qPCR) and in 128 paraffin-embedded CRC tissues using immunohistochemistry. The associations between ERRα expression and prognosis of CRC patients were evaluated by univariate, and multivariate (Cox proportional hazards model) analysis. RT-qPCR demonstrated that the mRNA expression of ERRα in CRC tissues was significantly higher compared with that in matched normal tissues. Immunohistochemistry revealed that ERRα high expression was detected in the nuclei of cancer cells from 39.1% (50/128) of CRC tissues. ERRα expression based on immunohistochemical staining was significantly associated with tumor differentiation, tumor invasion, lymph node status and Dukes stage (all P<0.05). Furthermore, patients with high ERRα expression were significantly associated with an increased risk of recurrence and poor prognosis, compared with patients with low ERRα expression. ERRα expression was identified as an independent prognostic factor for patients with CRC. In conclusion, ERRα serves important roles in the progression of CRC and is a potential prognostic factor for patients with CRC.

          Related collections

          Author and article information

          Journal
          Oncol Lett
          Oncol Lett
          OL
          Oncology Letters
          D.A. Spandidos
          1792-1074
          1792-1082
          April 2018
          09 February 2018
          09 February 2018
          : 15
          : 4
          : 5933-5939
          Affiliations
          [1 ]First Department of Chemotherapy, Affiliated Tumor Hospital of Guangxi Medical University, Nanning, Guangxi Zhuang Autonomous Region 530021, P.R. China
          [2 ]Department of Hepatobilliary Surgery, Affiliated Minzu Hospital of Guangxi Medical University, Nanning, Guangxi Zhuang Autonomous Region 530001, P.R. China
          Author notes
          Correspondence to: Professor Jia-Zhou Ye, First Department of Chemotherapy, Affiliated Tumor Hospital of Guangxi Medical University, 71 Hedi Road, Nanning, Guangxi Zhuang Autonomous Region 530021, P.R. China, E-mail: resident123@ 123456foxmail.com
          Professor Hai-Hong Ye, Department of Hepatobilliary Surgery, Affiliated Minzu Hospital of Guangxi Medical University, 232 East Mingxiu Road, Nanning, Guangxi Zhuang Autonomous Region 530001, P.R. China, E-mail: yehhgx@ 123456163.com
          Article
          PMC5840670 PMC5840670 5840670 OL-0-0-8011
          10.3892/ol.2018.8011
          5840670
          29552224
          c1748c75-b697-43de-a69f-10f33db45dc3
          Copyright © 2018, Spandidos Publications
          History
          : 28 July 2016
          : 21 December 2017
          Categories
          Articles

          estrogen-related receptor α,prognosis,colorectal cancer,local recurrence

          Comments

          Comment on this article