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      Alpha-inhibin is a tumour-suppressor gene with gonadal specificity in mice.

      Nature

      Animals, Female, Genes, Tumor Suppressor, Gonads, embryology, pathology, physiology, Heterozygote, Homozygote, Inhibins, deficiency, genetics, Male, Mice, Mice, Inbred C57BL, Mice, Transgenic, Mutagenesis, Ovarian Neoplasms, Testicular Neoplasms

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          Abstract

          The inhibins are alpha:beta heterodimeric growth factors that are members of the transforming growth factor-beta family. To understand the physiological roles of the inhibins in mammalian development and reproduction, a targeted deletion of the alpha-inhibin gene was generated by homologous recombination in mouse embryonic stem cells. Mice homozygous for the null allele (inhibin-deficient) initially develop normally but every mouse ultimately develops mixed or incompletely differentiated gonadal stromal tumours either unilaterally or bilaterally. Inhibin is thus a critical negative regulator of gonadal stromal cell proliferation and the first secreted protein identified to have tumour-suppressor activity.

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          Journal
          1448148
          10.1038/360313a0

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