Rare and Multiple Alloimmunization in Antenatal Women: A Case Report

ABSTRACT

Maternal alloimmunization is uncommon and highly variable, and general obstetricians are not familiar with, non-ABO, non-D alloimmunization. Therefore, when a woman with anti-D alloimmunization, who has received antibody prophylaxis, still develops fetal anemia in a subsequent pregnancy, it is commonly labeled as inadequate prophylaxis or a coincidental non-immune cause of fetal anemia. We report a similar case of unusual and multiple alloimmunization, where anti-D, anti-C, and anti-U antibodies were present resulting in hemolytic disease of the fetus and newborn (HDFN). The case emphasizes the need for routine and periodic antibody screening in all pregnant women, irrespective of their ABO and Rh status, which will allow monitoring from early pregnancy and timely intervention to avoid poor fetal and neonatal outcomes.

How to cite this article

Garg S, Payal V, Sharma U, et al. Rare and Multiple Alloimmunization in Antenatal Women: A Case Report. J South Asian Feder Obst Gynae 2023;15(3):362–364.