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      Four New Glycosides from the Rhizoma of Anemarrhena asphodeloides

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          Abstract

          Four new compounds, aneglycoside A–C ( 13) and timosaponin U ( 4), were isolated from the rhizomes of Anemarrhena asphodeloides. Their structures were determined through extensive spectroscopic analysis, chemical characteristics, and high-resolution mass spectrometry (HRMS). All the isolations were evaluated for cytotoxicity against HepG2, Hela, and SGC7901 human cancer lines. Compounds 1, 2, and 4 showed weak antiproliferative activities on HepG2, Hela, and SGC7901 cells.

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          Steroidal saponins from the whole plants of Agave utahensis and their cytotoxic activity.

          Phytochemical investigation of the whole plants of Agave utahensis Engelm. (Agavaceae) has resulted in the isolation of 15 steroidal saponins (1-15), including five spirostanol saponins (1-5) and three furostanol saponins (11-13). Structures of compounds 1-5 and 11-13 were determined by spectroscopic analysis and the results of hydrolytic cleavage. The isolated compounds were evaluated for their cytotoxic activity against HL-60 human promyelocytic leukemia cells.
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            Antioxidant Glucosylated Caffeoylquinic Acid Derivatives in the Invasive Tropical Soda Apple, Solanum viarum

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              Five Withanolides from the Leaves of Datura metel L. and Their Inhibitory Effects on Nitric Oxide Production

              Four new withanolides named dmetelins A–D (compounds 1–4), along with the known compound 7α,27-dihydroxy-1-oxo-witha-2,5,24-trienolide (5) were isolated from the leaves of Datura metel L. (Solanaceae). Their structures were elucidated on the basis of detailed analysis of 1D and 2D NMR and mass spectrometry data. All the compounds were evaluated for their inhibitory effects on lipopolysaccharide (LPS)-induced nitric oxide (NO) production in RAW 264.7 cells. Compounds 1, 4 and 5 showed significant inhibitory activities, and compounds 2 and 3 showed moderate inhibitory activities with IC50 values of 17.8, 11.6, 14.9, 33.3 and 28.6 μM, respectively.
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                Author and article information

                Journal
                Molecules
                Molecules
                molecules
                Molecules : A Journal of Synthetic Chemistry and Natural Product Chemistry
                MDPI
                1420-3049
                22 November 2017
                November 2017
                : 22
                : 11
                : 1995
                Affiliations
                [1 ]Key Laboratory of Chinese Materia Medica, Ministry of Education of Heilongjiang, University of Chinese Medicine, Harbin 150040, China; ybywater@ 123456163.com (B.-Y.Y.); lifeliuyan@ 123456163.com (Y.L.); yinxin110901@ 123456163.com (X.Y.)
                [2 ]Heilongjiang Institute for Food and Drug Control, Harbin 150001, China; hljbixueyan@ 123456sina.cn
                [3 ]College of Pharmacy, Harbin University of Commerce, Harbin 150001, China; Leegy@ 123456163.com
                Author notes
                [* ]Correspondence: hxkuang@ 123456hotmail.com ; Tel.: +86-0451-8219-7188
                [†]

                These authors contributed equally to this work.

                Article
                molecules-22-01995
                10.3390/molecules22111995
                6150167
                29165329
                c19770f0-e1fd-4e9f-acb1-43cb2d2f9017
                © 2017 by the authors.

                Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license ( http://creativecommons.org/licenses/by/4.0/).

                History
                : 28 October 2017
                : 15 November 2017
                Categories
                Article

                asparagaceae,natural product,pyroglutamic acid,disaccharide,steroidal saponins,cytotoxicity

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