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      Immunohistochemical localization of activated and mature CD83+ dendritic cells in granulomas of sporotrichosis.

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      European journal of dermatology : EJD

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          Abstract

          Dendritic cells (DC) are considered to be the most potent antigen-presenting cells (APC) and CD83 is expressed at a high level on immune-competent, activated and mature DC. In order to obtain insight into the immune response in sporotrichosis, we searched immunohistochemically for CD83+ DC in the granulomatous skin lesions of patients. A small but significant subpopulation of CD83+ DC (approximately 0.2 to 0.8% of inflammatory cells) was found. The most common distribution pattern of CD83+ DC was as clusters with mononuclear lymphoid cells within the granulomas. In addition, CD83+ DC were occasionally scattered around the granulomas. High-intensity staining of CD83 antigens was detected not only on the surface, but also in the cytoplasm of DC. No CD83+ DC were observed in the epidermis. A considerable amount of CD1a+ cells were detected in the epidermis, papillary dermis and around the granulomas, but CD1a+ cells were rarely found within the granulomas. There were large numbers of CD68+ monocytes and macrophages in the granulomas. These results indicate that activated and mature DC may play a role in the immune response to sporotrichosis.

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          Author and article information

          Journal
          Eur J Dermatol
          European journal of dermatology : EJD
          1167-1122
          1167-1122
          November 10 2001
          : 11
          : 6
          Affiliations
          [1 ] Department of Dermatology, Graduate School of Medical Sciences, Kyushu University, 3-1-1, Maidashi, Higashi-ku, J-812-8582 Fukuoka, Japan. tekoga@dermatol.med.kyushu-u.ac.jp
          Article
          11701401

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