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      Antiangiogenic actions of vascular endothelial growth factor-A165b, an inhibitory isoform of vascular endothelial growth factor-A, in human obesity.

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          Abstract

          Experimental studies suggest that visceral adiposity and adipose tissue dysfunction play a central role in obesity-related cardiometabolic complications. Impaired angiogenesis in fat has been implicated in the development of adipose tissue hypoxia, capillary rarefaction, inflammation, and metabolic dysregulation, but pathophysiological mechanisms remain unknown. In this study, we examined the role of a novel antiangiogenic isoform of vascular endothelial growth factor-A (VEGF-A), VEGF-A165b, in human obesity.

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          Journal
          Journal ID (iso-abbrev): Circulation
          Title: Circulation
          ISSN (Electronic): 1524-4539
          ISSN (Print): 0009-7322
          Publication date (Electronic): Sep 23 2014
          Volume: 130
          Issue: 13
          Affiliations
          [1 ] From the Evans Department of Medicine and Whitaker Cardiovascular Institute (D.T.M.N., M.G.F., R.K., S.K., S.T., S.J.B., N.M.H., J.A.V., K.W., N.G.) and Department of General Surgery (D.T.H.), Boston University School of Medicine, Boston, MA; Microvascular Research Laboratories, School of Physiology and Pharmacology, Bristol Heart Institute, School of Veterinary Science, University of Bristol, Bristol, UK (D.O.B.); and Department of Biostatistics, Boston University School of Public Health, Boston, MA (M.P.L.).
          [2 ] From the Evans Department of Medicine and Whitaker Cardiovascular Institute (D.T.M.N., M.G.F., R.K., S.K., S.T., S.J.B., N.M.H., J.A.V., K.W., N.G.) and Department of General Surgery (D.T.H.), Boston University School of Medicine, Boston, MA; Microvascular Research Laboratories, School of Physiology and Pharmacology, Bristol Heart Institute, School of Veterinary Science, University of Bristol, Bristol, UK (D.O.B.); and Department of Biostatistics, Boston University School of Public Health, Boston, MA (M.P.L.). Noyan.Gokce@bmc.org.
          Article
          Publisher Item ID: CIRCULATIONAHA.113.008171 Mid ID: NIHMS612492
          DOI: 10.1161/CIRCULATIONAHA.113.008171
          PMC ID: 4175289
          PubMed ID: 25116954
          SO-VID: c1b1bbd1-88b6-468c-9b5e-636cb3e3b66e
          Copyright © © 2014 American Heart Association, Inc.
          History

          Keywords: angiogenesis modulating agents,intra-abdominal fat,metabolism,obesity,vascular endothelial growth factor A,vascular endothelial growth factors
          Data availability:
          Keywords: angiogenesis modulating agents, intra-abdominal fat, metabolism, obesity, vascular endothelial growth factor A, vascular endothelial growth factors

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