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      Polyketides with potential bioactivities from the mangrove-derived fungus Talaromyces sp. WHUF0362


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          Metabolites of microorganisms have long been considered as potential sources for drug discovery. In this study, five new depsidone derivatives, talaronins A-E ( 1–5) and three new xanthone derivatives, talaronins F–H ( 6–8), together with 16 known compounds ( 9–24), were isolated from the ethyl acetate extract of the mangrove-derived fungus Talaromyces species WHUF0362. The structures were elucidated by analysis of spectroscopic data and chemical methods including alkaline hydrolysis and Mosher’s method. Compounds 1 and 2 each attached a dimethyl acetal group at the aromatic ring. A putative biogenetic relationship of the isolated metabolites was presented and suggested that the depsidones and the xanthones probably had the same biosynthetic precursors such as chrysophanol or rheochrysidin. The antimicrobial activity assay indicated that compounds 5, 9, 10, and 14 showed potent activity against Helicobacter pylori with minimum inhibitory concentration (MIC) values in the range of 2.42–36.04 μmol/L. While secalonic acid D ( 19) demonstrated significant antimicrobial activity against four strains of H. pylori with MIC values in the range of 0.20 to 1.57 μmol/L. Furthermore, secalonic acid D ( 19) exhibited cytotoxicity against cancer cell lines Bel-7402 and HCT-116 with IC 50 values of 0.15 and 0.19 μmol/L, respectively. The structure–activity relationship of depsidone derivatives revealed that the presence of the lactone ring and the hydroxyl at C-10 was crucial to the antimicrobial activity against H. pylori. The depsidone derivatives are promising leads to inhibit H. pylori and provide an avenue for further development of novel antibiotics.

          Supplementary Information

          The online version contains supplementary material available at 10.1007/s42995-023-00170-5.

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          Most cited references41

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          Xanthones from fungi, lichens, and bacteria: the natural products and their synthesis.

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            Bioactive Compounds Produced by Strains of Penicillium and Talaromyces of Marine Origin

            In recent years, the search for novel natural compounds with bioactive properties has received a remarkable boost in view of their possible pharmaceutical exploitation. In this respect the sea is entitled to hold a prominent place, considering the potential of the manifold animals and plants interacting in this ecological context, which becomes even greater when their associated microbes are considered for bioprospecting. This is the case particularly of fungi, which have only recently started to be considered for their fundamental contribution to the biosynthetic potential of other more valued marine organisms. Also in this regard, strains of species which were previously considered typical terrestrial fungi, such as Penicillium and Talaromyces, disclose foreground relevance. This paper offers an overview of data published over the past 25 years concerning the production and biological activities of secondary metabolites of marine strains belonging to these genera, and their relevance as prospective drugs.
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              RecA Inhibitors Potentiate Antibiotic Activity and Block Evolution of Antibiotic Resistance.

              Antibiotic resistance arises from the maintenance of resistance mutations or genes acquired from the acquisition of adaptive de novo mutations or the transfer of resistance genes. Antibiotic resistance is acquired in response to antibiotic therapy by activating SOS-mediated DNA repair and mutagenesis and horizontal gene transfer pathways. Initiation of the SOS pathway promotes activation of RecA, inactivation of LexA repressor, and induction of SOS genes. Here, we have identified and characterized phthalocyanine tetrasulfonic acid RecA inhibitors that block antibiotic-induced activation of the SOS response. These inhibitors potentiate the activity of bactericidal antibiotics, including members of the quinolone, β-lactam, and aminoglycoside families in both Gram-negative and Gram-positive bacteria. They reduce the ability of bacteria to acquire antibiotic resistance mutations and to transfer mobile genetic elements conferring resistance. This study highlights the advantage of including RecA inhibitors in bactericidal antibiotic therapies and provides a new strategy for prolonging antibiotic shelf life.

                Author and article information

                Mar Life Sci Technol
                Mar Life Sci Technol
                Marine Life Science & Technology
                Springer Nature Singapore (Singapore )
                31 March 2023
                31 March 2023
                May 2023
                : 5
                : 2
                : 232-241
                [1 ]GRID grid.469325.f, ISNI 0000 0004 1761 325X, College of Pharmaceutical Science & Key Laboratory of Marine Fishery Resources Exploitment & Utilization of Zhejiang Province, , Zhejiang University of Technology, ; Hangzhou, 310014 China
                [2 ]GRID grid.49470.3e, ISNI 0000 0001 2331 6153, School of Pharmaceutical Sciences, , Wuhan University, ; Wuhan, 430072 China
                [3 ]GRID grid.89957.3a, ISNI 0000 0000 9255 8984, Department of Pathogen Biology & Jiangsu Key Laboratory of Pathogen Biology, , Nanjing Medical University, ; Nanjing, 211166 China
                [4 ]GRID grid.506261.6, ISNI 0000 0001 0706 7839, Beijing Key Laboratory of Drug Target Research and New Drug Screening, Institute of Materia Medica, , Chinese Academy of Medical Sciences, ; Beijing, 100700 China
                [5 ]GRID grid.469325.f, ISNI 0000 0004 1761 325X, Research Center of Analysis and Measurement, , Zhejiang University of Technology, ; Hangzhou, 310014 China
                [6 ]GRID grid.419725.c, ISNI 0000 0001 2151 8157, Department of Phytochemistry and Plant Systematics, , National Research Centre, ; Giza, Egypt
                Author notes

                Edited by Chengchao Chen.

                © The Author(s) 2023

                Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

                : 25 April 2022
                : 12 January 2023
                Research Paper
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                © Ocean University of China 2023

                mangrove-derived fungus,talaromyces sp.,depsidone,xanthone,antimicrobial


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