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      A pharmacodynamic approach to antimicrobial activity in serum and epithelial lining fluid against in vivo-selected Streptococcus pneumoniae mutants and association with clinical failure in pneumonia.

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          Abstract

          Emergence of resistance may be prevented by killing both the parental infecting strain and subsequent less susceptible step-mutants. The present study analyses eradication and resistance selection in Streptococcus pneumoniae with moxifloxacin, levofloxacin and azithromycin, using a parental serotype 3 clinical strain (strain A) and its correspondent step-mutant derivatives resistant to these antibiotics (B, C, D), which were selected in vivo in a patient with pneumonia.

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          Author and article information

          Journal
          J. Antimicrob. Chemother.
          The Journal of antimicrobial chemotherapy
          Oxford University Press (OUP)
          0305-7453
          0305-7453
          Aug 2006
          : 58
          : 2
          Affiliations
          [1 ] Microbiology Department, School of Medicine, Universidad Complutense Avda. Complutense s/n, 28040 Madrid, and Microbiology Department, Hospital Donostia, San Sebastián, Spain.
          Article
          dkl250
          10.1093/jac/dkl250
          16782744
          c1da77a1-1c58-4dc1-ade8-7dc984746d08
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