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      Results of Long-Term Therapy with Growth Hormone in Two Dose Regimens in Turner Syndrome

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          Girls with Turner syndrome were divided according to age (group A 6-12 years, and group B 12-19 years) and human growth hormone (GH) dose regimen (Al and Bl, three injections/week; A2 and B2, six injections/week). All groups responded to GH, 24 IU/m<sup>2</sup>/week, with an increase in height velocity, though in the older girls, the response was comparatively poor. Therefore, the dose regimens in groups B1 and B2 were increased to 36 IU/m<sup>2</sup>/week given as six injections in both groups. This change resulted in an increase in height velocity only in group B1. During the first 2 years only, the height velocity was greater in group A2 than group A1. The conclusion is that a regimen of six injections/week is more effective than one of three injections/week in terms of initial height gain and change in predicted adult height. In girls with Turner syndrome aged over 16 years, GH therapy has no significant effect.

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          Author and article information

          Hormone Research in Paediatrics
          S. Karger AG
          03 December 2008
          : 39
          : Suppl 2
          : 31-36
          Departments of Paediatrics of the Universities of aUtrecht, bNijmegen, cRotterdam, dGroningen, eAmsterdam Free University, fAmsterdam, and gLeiden, and hCatherina Hospital, Eindhoven, The Netherlands
          182765 Horm Res 1993;39:31–36
          © 1993 S. Karger AG, Basel

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          Page count
          Pages: 6
          Session II Dosing hGH in Turner Syndrome


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