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      Differentiating Transition Zone Cancers From Benign Prostatic Hyperplasia by Quantitative Multiparametric Magnetic Resonance Imaging

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          Abstract

          Objective:

          The aim of this study was to evaluate the value of quantitative diffusion and perfusion parameters to aid in discriminating between transition zone carcinomas and benign prostatic hyperplasia (BPH).

          Materials and Methods:

          Twenty-four transition zone cancers and BPH nodules were contoured on T2-weighted magnetic resonance imaging (MRI), apparent diffusion coefficient (ADC) maps, and raw dynamic contrast-enhanced (DCE) MRI. Benign prostatic hyperplasia nodules were then stratified into 2 groups based on the presence or absence of a capsule. Apparent diffusion coefficient values, per-voxel K trans, k ep, v p, and v e were all compared across all groups.

          Results:

          Average ADCs (×10 −6 mm 2/s) were 1019.22, 1338.11, and 1272.46 for cancer, encapsulated BPH, and nonencapsulated BPH, respectively. Both subgroups of BPH were found to be significantly different than that of cancer ( P < 0.05). No individual DCE-MRI parameter was significantly different between cancer and either BPH group. The area under the curve for ADC alone was 0.83, and no individual DCE imaging parameter improved the area under the curve of ADC.

          Conclusions:

          Apparent diffusion coefficient may play a role in distinguishing TZ cancers from non-encapsulated BPH nodules that closely resemble cancer.

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          Author and article information

          Journal
          7703942
          4674
          J Comput Assist Tomogr
          J Comput Assist Tomogr
          Journal of computer assisted tomography
          0363-8715
          1532-3145
          24 December 2020
          Mar-Apr 2016
          06 January 2021
          : 40
          : 2
          : 218-224
          Affiliations
          [* ]Molecular Imaging Program, National Cancer Institute, National Institutes of Health, Bethesda, MD
          []iCAD, Inc, Nashua, NH
          []Division of Cancer Treatment and Diagnosis, Biometric Research Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD
          [§ ]Imaging Physics, SAIC Frederick, Inc, National Cancer Institute-Frederick, Frederick, MD
          [ǁ ]Laboratory of Pathology, National Cancer Institute, National Institutes of Health, Bethesda, MD
          []Center for Interventional Oncology, National Cancer Institute, National Institutes of Health, Bethesda, MD.
          [# ]Urologic Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD.
          Author notes
          Correspondence to: Baris Turkbey, MD, Molecular Imaging Program, National Cancer Institute, 10 Center Dr, MSC 1182, Bldg 10, Room B3B85, Bethesda, MD 20892-1088 ( turkbeyi@ 123456mail.nih.gov ).
          Article
          PMC7787362 PMC7787362 7787362 nihpa1655132
          10.1097/RCT.0000000000000353
          7787362
          26760185
          Categories
          Article

          transition zone, prostate cancer, BPH, multiparametric MRI

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