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      Immediate Induction of c- fos and c- myc Transcripts following Unilateral Nephrectomy

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          Abstract

          Unilateral nephrectomy in the rat results in contralateral compensatory renal growth. The immediate molecular events which occur in the remaining renal unit were studied by examining RNA isolated from these kidneys. Northern blot analysis was used to analyze the expression of the growth-related (c- fos and c- myc) genes during the 1-hour period following unilateral nephrectomy. Both c- fos and c- myc band transcripts were detected within 15 min after nephrectomy. The immediate, transient induction of these genes in the remaining renal unit mimics that seen during proliferative stimulation of cultured cells and may play a role in modulating the eventual compensatory growth response.

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          Author and article information

          Journal
          NEF
          Nephron
          10.1159/issn.1660-8151
          Nephron
          S. Karger AG
          1660-8151
          2235-3186
          1990
          1990
          10 December 2008
          : 55
          : 2
          : 193-195
          Affiliations
          Department of Urology, College of Physicians and Surgeons, Columbia University, New York, N.Y., USA
          Article
          185951 Nephron 1990;55:193–195
          10.1159/000185951
          2113996
          © 1990 S. Karger AG, Basel

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          Page count
          Pages: 3
          Categories
          Original Paper

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