Immediate Induction of c- fos  and c- myc  Transcripts following Unilateral Nephrectomy

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Abstract

Unilateral nephrectomy in the rat results in contralateral compensatory renal growth. The immediate molecular events which occur in the remaining renal unit were studied by examining RNA isolated from these kidneys. Northern blot analysis was used to analyze the expression of the growth-related (c- fos and c- myc) genes during the 1-hour period following unilateral nephrectomy. Both c- fos and c- myc band transcripts were detected within 15 min after nephrectomy. The immediate, transient induction of these genes in the remaining renal unit mimics that seen during proliferative stimulation of cultured cells and may play a role in modulating the eventual compensatory growth response.

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Journal ID (publisher-id): NEF

Journal ID (nlm-ta): Nephron

Journal ID (doi): 10.1159/issn.1660-8151

Title: Nephron

Publisher: S. Karger AG

ISSN (Print): 1660-8151

ISSN (Electronic): 2235-3186

Publication date Subscription-year: 1990

Publication date (Print): 1990

Publication date (Electronic): 10 December 2008

Volume: 55

Issue: 2

Pages: 193-195

Affiliations

Department of Urology, College of Physicians and Surgeons, Columbia University, New York, N.Y., USA

Article

Publisher ID: 185951 Other ID: Nephron 1990;55:193–195

DOI: 10.1159/000185951

PubMed ID: 2113996

SO-VID: c1f6d43a-f432-4c71-9f9f-f3f3a3fbb7f9

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Immediate Induction of c- fos and c- myc Transcripts following Unilateral Nephrectomy

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Karger: Nephrology

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