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      Blood Viscosity Factors and Occlusive Arterial Disease in Renal Transplant Recipients

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          Abstract

          29 cadaveric renal transplant recipients were assessed clinically for evidence of occlusive arterial disease prior to undergoing blood viscosity studies. Nineteen patients had manifest arterial disease (myocardial infarction, cerebral thrombosis, angina, intermittent claudication, absent peripheral pulses), while ten were free from vascular complications. Patients with arterial disease showed significant elevations of plasma viscosity (p < 0.005), aggregation of red cells measured both at 37 and 20°C (p < 0.05), fibrinogen (p < 0.005), serum triglyceride (p < 0.01), serum cholesterol (p < 0.01), erythrocyte sedimentation rate (p < 0.02), and a significant reduction in the albumin/fibrinogen ratio (p < 0.005) when compared with those free of disease. Two patients with no apparent vascular disease when investigated were found to have distinctly abnormal blood viscosity factors, and one subsequently developed retinal arterial thrombosis while the other suffered serious damage of the graft within 3 months of viscosity study. When all patients were considered together, significant correlations were found between viscosity of artificial thrombi or aggregation of red cells and fibrinogen level (both p < 0.05), and serum triglyceride level (both p < 0.05); and between rigidity of red cells and the parathyroid hormone level (p < 0.01).

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          Author and article information

          Journal
          NEF
          Nephron
          10.1159/issn.1660-8151
          Nephron
          S. Karger AG
          1660-8151
          2235-3186
          1975
          1975
          28 November 2008
          : 15
          : 6
          : 456-465
          Affiliations
          Haemorheology Unit and Medical Research, Sydney Hospital, and Department of Medicine, University of Sydney; and Renal Unit and Medical Research, Kanematsu Memorial Institute, Sydney Hospital, Sydney, Australia
          Article
          180529 Nephron 1975;15:456–465
          10.1159/000180529
          1105219
          © 1975 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          Page count
          Pages: 10
          Categories
          Original Paper

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